HEADER TRANSCRIPTION 31-DEC-24 9HVO TITLE STRUCTURE OF THE TRANSCRIBING POL II-RECQL5 COMPLEX COMPND MOL_ID: 1; COMPND 2 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT; COMPND 3 CHAIN: A; COMPND 4 EC: 2.7.7.6; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA; COMPND 7 CHAIN: B; COMPND 8 EC: 2.7.7.6; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3; COMPND 11 CHAIN: C; COMPND 12 SYNONYM: RNA POLYMERASE II SUBUNIT C; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: RNA POLYMERASE II SUBUNIT D; COMPND 15 CHAIN: D; COMPND 16 MOL_ID: 5; COMPND 17 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT E; COMPND 18 CHAIN: E; COMPND 19 SYNONYM: RPB5 HOMOLOG; COMPND 20 MOL_ID: 6; COMPND 21 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2; COMPND 22 CHAIN: F; COMPND 23 SYNONYM: DNA-DIRECTED RNA POLYMERASE II SUBUNIT F,RPB6 HOMOLOG; COMPND 24 MOL_ID: 7; COMPND 25 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT; COMPND 26 CHAIN: G; COMPND 27 MOL_ID: 8; COMPND 28 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3; COMPND 29 CHAIN: H; COMPND 30 MOL_ID: 9; COMPND 31 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9; COMPND 32 CHAIN: I; COMPND 33 SYNONYM: RNA POLYMERASE II SUBUNIT B9,DNA-DIRECTED RNA POLYMERASE II COMPND 34 SUBUNIT I,RNA POLYMERASE II 14.5 KDA SUBUNIT,RPB14.5; COMPND 35 MOL_ID: 10; COMPND 36 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5; COMPND 37 CHAIN: J; COMPND 38 MOL_ID: 11; COMPND 39 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11-A; COMPND 40 CHAIN: K; COMPND 41 MOL_ID: 12; COMPND 42 MOLECULE: RNA POLYMERASE II, I AND III SUBUNIT K; COMPND 43 CHAIN: L; COMPND 44 MOL_ID: 13; COMPND 45 MOLECULE: NONTEMPLATE DNA; COMPND 46 CHAIN: N; COMPND 47 ENGINEERED: YES; COMPND 48 MOL_ID: 14; COMPND 49 MOLECULE: RNA; COMPND 50 CHAIN: P; COMPND 51 ENGINEERED: YES; COMPND 52 MOL_ID: 15; COMPND 53 MOLECULE: TEMPLATE DNA; COMPND 54 CHAIN: T; COMPND 55 ENGINEERED: YES; COMPND 56 MOL_ID: 16; COMPND 57 MOLECULE: ATP-DEPENDENT DNA HELICASE Q5; COMPND 58 CHAIN: O; COMPND 59 SYNONYM: DNA 3'-5' HELICASE RECQ5,DNA HELICASE,RECQ-LIKE TYPE 5, COMPND 60 RECQ5,RECQ PROTEIN-LIKE 5; COMPND 61 EC: 5.6.2.4; COMPND 62 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 3 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 4 ORGANISM_TAXID: 9825; SOURCE 5 MOL_ID: 2; SOURCE 6 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 7 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 8 ORGANISM_TAXID: 9825; SOURCE 9 MOL_ID: 3; SOURCE 10 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 11 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 12 ORGANISM_TAXID: 9825; SOURCE 13 MOL_ID: 4; SOURCE 14 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 15 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 16 ORGANISM_TAXID: 9825; SOURCE 17 MOL_ID: 5; SOURCE 18 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 19 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 20 ORGANISM_TAXID: 9825; SOURCE 21 MOL_ID: 6; SOURCE 22 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 23 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 24 ORGANISM_TAXID: 9825; SOURCE 25 MOL_ID: 7; SOURCE 26 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 27 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 28 ORGANISM_TAXID: 9825; SOURCE 29 MOL_ID: 8; SOURCE 30 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 31 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 32 ORGANISM_TAXID: 9825; SOURCE 33 MOL_ID: 9; SOURCE 34 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 35 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 36 ORGANISM_TAXID: 9825; SOURCE 37 MOL_ID: 10; SOURCE 38 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 39 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 40 ORGANISM_TAXID: 9825; SOURCE 41 MOL_ID: 11; SOURCE 42 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 43 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 44 ORGANISM_TAXID: 9825; SOURCE 45 MOL_ID: 12; SOURCE 46 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS; SOURCE 47 ORGANISM_COMMON: DOMESTIC PIG; SOURCE 48 ORGANISM_TAXID: 9825; SOURCE 49 MOL_ID: 13; SOURCE 50 SYNTHETIC: YES; SOURCE 51 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 52 ORGANISM_TAXID: 32630; SOURCE 53 MOL_ID: 14; SOURCE 54 SYNTHETIC: YES; SOURCE 55 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 56 ORGANISM_TAXID: 32630; SOURCE 57 MOL_ID: 15; SOURCE 58 SYNTHETIC: YES; SOURCE 59 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 60 ORGANISM_TAXID: 32630; SOURCE 61 MOL_ID: 16; SOURCE 62 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 63 ORGANISM_COMMON: HUMAN; SOURCE 64 ORGANISM_TAXID: 9606; SOURCE 65 GENE: RECQL5, RECQ5; SOURCE 66 EXPRESSION_SYSTEM: TRICHOPLUSIA NI; SOURCE 67 EXPRESSION_SYSTEM_TAXID: 7111 KEYWDS TRANSCRIPTION ELONGATION, DNA HELICASE, TRANSCRIPTION-COUPLED REPAIR, KEYWDS 2 RNA POLYMERASE II, TRANSCRIPTION EXPDTA ELECTRON MICROSCOPY AUTHOR L.ZHANG,S.ZHANG REVDAT 1 16-JUL-25 9HVO 0 JRNL AUTH L.ZHANG,Y.GORDIYENKO,T.MORGAN,C.FRANCO, JRNL AUTH 2 A.TUFEGDZIC VIDAKOVIC,S.ZHANG JRNL TITL STRUCTURAL BASIS OF RECQL5-INDUCED RNA POLYMERASE II JRNL TITL 2 TRANSCRIPTION BRAKING AND SUBSEQUENT REACTIVATION. JRNL REF NAT.STRUCT.MOL.BIOL. 2025 JRNL REFN ESSN 1545-9985 JRNL PMID 40624163 JRNL DOI 10.1038/S41594-025-01586-6 REMARK 2 REMARK 2 RESOLUTION. 2.80 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.800 REMARK 3 NUMBER OF PARTICLES : 66771 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9HVO COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 31-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1292144303. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : EC-RECQL5 COMPLEX REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.20 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 8602 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4270.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 96000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 16-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 16-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, N, P, T, O REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 HIS A 2 REMARK 465 GLY A 3 REMARK 465 GLY A 4 REMARK 465 GLY A 5 REMARK 465 PRO A 6 REMARK 465 PRO A 7 REMARK 465 SER A 8 REMARK 465 GLY A 9 REMARK 465 ASP A 10 REMARK 465 GLY A 156 REMARK 465 GLY A 157 REMARK 465 GLU A 158 REMARK 465 GLU A 159 REMARK 465 MET A 160 REMARK 465 ASP A 161 REMARK 465 ASN A 162 REMARK 465 LYS A 163 REMARK 465 PHE A 164 REMARK 465 GLY A 165 REMARK 465 VAL A 166 REMARK 465 GLU A 167 REMARK 465 GLN A 168 REMARK 465 PRO A 169 REMARK 465 GLU A 170 REMARK 465 GLY A 171 REMARK 465 ASP A 172 REMARK 465 GLU A 173 REMARK 465 ASP A 174 REMARK 465 LEU A 175 REMARK 465 THR A 176 REMARK 465 LYS A 177 REMARK 465 GLU A 178 REMARK 465 LYS A 179 REMARK 465 GLY A 180 REMARK 465 HIS A 181 REMARK 465 THR A 1106 REMARK 465 PHE A 1107 REMARK 465 HIS A 1108 REMARK 465 TYR A 1109 REMARK 465 ALA A 1110 REMARK 465 GLY A 1111 REMARK 465 VAL A 1112 REMARK 465 SER A 1113 REMARK 465 SER A 1264 REMARK 465 ASP A 1265 REMARK 465 GLU A 1266 REMARK 465 ASN A 1267 REMARK 465 LYS A 1268 REMARK 465 MET A 1269 REMARK 465 GLN A 1270 REMARK 465 GLU A 1271 REMARK 465 GLU A 1272 REMARK 465 GLU A 1273 REMARK 465 GLU A 1274 REMARK 465 VAL A 1275 REMARK 465 VAL A 1276 REMARK 465 ASP A 1277 REMARK 465 LYS A 1278 REMARK 465 TYR A 1482 REMARK 465 GLY A 1483 REMARK 465 MET A 1484 REMARK 465 GLU A 1485 REMARK 465 ILE A 1486 REMARK 465 PRO A 1487 REMARK 465 THR A 1488 REMARK 465 ASN A 1489 REMARK 465 ILE A 1490 REMARK 465 PRO A 1491 REMARK 465 GLY A 1492 REMARK 465 LEU A 1493 REMARK 465 GLY A 1494 REMARK 465 ALA A 1495 REMARK 465 ALA A 1496 REMARK 465 GLY A 1497 REMARK 465 PRO A 1498 REMARK 465 THR A 1499 REMARK 465 GLY A 1500 REMARK 465 MET A 1501 REMARK 465 PHE A 1502 REMARK 465 PHE A 1503 REMARK 465 GLY A 1504 REMARK 465 SER A 1505 REMARK 465 ALA A 1506 REMARK 465 PRO A 1507 REMARK 465 SER A 1508 REMARK 465 PRO A 1509 REMARK 465 MET A 1510 REMARK 465 GLY A 1511 REMARK 465 GLY A 1512 REMARK 465 ILE A 1513 REMARK 465 SER A 1514 REMARK 465 PRO A 1515 REMARK 465 ALA A 1516 REMARK 465 MET A 1517 REMARK 465 THR A 1518 REMARK 465 PRO A 1519 REMARK 465 TRP A 1520 REMARK 465 ASN A 1521 REMARK 465 GLN A 1522 REMARK 465 GLY A 1523 REMARK 465 ALA A 1524 REMARK 465 THR A 1525 REMARK 465 PRO A 1526 REMARK 465 ALA A 1527 REMARK 465 TYR A 1528 REMARK 465 GLY A 1529 REMARK 465 ALA A 1530 REMARK 465 TRP A 1531 REMARK 465 SER A 1532 REMARK 465 PRO A 1533 REMARK 465 SER A 1534 REMARK 465 VAL A 1535 REMARK 465 GLY A 1536 REMARK 465 SER A 1537 REMARK 465 GLY A 1538 REMARK 465 MET A 1539 REMARK 465 THR A 1540 REMARK 465 PRO A 1541 REMARK 465 GLY A 1542 REMARK 465 ALA A 1543 REMARK 465 ALA A 1544 REMARK 465 GLY A 1545 REMARK 465 PHE A 1546 REMARK 465 SER A 1547 REMARK 465 PRO A 1548 REMARK 465 SER A 1549 REMARK 465 ALA A 1550 REMARK 465 ALA A 1551 REMARK 465 SER A 1552 REMARK 465 ASP A 1553 REMARK 465 ALA A 1554 REMARK 465 SER A 1555 REMARK 465 GLY A 1556 REMARK 465 PHE A 1557 REMARK 465 SER A 1558 REMARK 465 PRO A 1559 REMARK 465 GLY A 1560 REMARK 465 TYR A 1561 REMARK 465 SER A 1562 REMARK 465 PRO A 1563 REMARK 465 ALA A 1564 REMARK 465 TRP A 1565 REMARK 465 SER A 1566 REMARK 465 PRO A 1567 REMARK 465 THR A 1568 REMARK 465 PRO A 1569 REMARK 465 GLY A 1570 REMARK 465 SER A 1571 REMARK 465 PRO A 1572 REMARK 465 GLY A 1573 REMARK 465 SER A 1574 REMARK 465 PRO A 1575 REMARK 465 GLY A 1576 REMARK 465 PRO A 1577 REMARK 465 SER A 1578 REMARK 465 SER A 1579 REMARK 465 PRO A 1580 REMARK 465 TYR A 1581 REMARK 465 ILE A 1582 REMARK 465 PRO A 1583 REMARK 465 SER A 1584 REMARK 465 PRO A 1585 REMARK 465 GLY A 1586 REMARK 465 GLY A 1587 REMARK 465 ALA A 1588 REMARK 465 MET A 1589 REMARK 465 SER A 1590 REMARK 465 PRO A 1591 REMARK 465 SER A 1592 REMARK 465 TYR A 1593 REMARK 465 SER A 1594 REMARK 465 PRO A 1595 REMARK 465 THR A 1596 REMARK 465 SER A 1597 REMARK 465 PRO A 1598 REMARK 465 ALA A 1599 REMARK 465 TYR A 1600 REMARK 465 GLU A 1601 REMARK 465 PRO A 1602 REMARK 465 ARG A 1603 REMARK 465 SER A 1604 REMARK 465 PRO A 1605 REMARK 465 GLY A 1606 REMARK 465 GLY A 1607 REMARK 465 TYR A 1608 REMARK 465 THR A 1609 REMARK 465 PRO A 1610 REMARK 465 GLN A 1611 REMARK 465 SER A 1612 REMARK 465 PRO A 1613 REMARK 465 SER A 1614 REMARK 465 TYR A 1615 REMARK 465 SER A 1616 REMARK 465 PRO A 1617 REMARK 465 THR A 1618 REMARK 465 SER A 1619 REMARK 465 PRO A 1620 REMARK 465 SER A 1621 REMARK 465 TYR A 1622 REMARK 465 SER A 1623 REMARK 465 PRO A 1624 REMARK 465 THR A 1625 REMARK 465 SER A 1626 REMARK 465 PRO A 1627 REMARK 465 SER A 1628 REMARK 465 TYR A 1629 REMARK 465 SER A 1630 REMARK 465 PRO A 1631 REMARK 465 THR A 1632 REMARK 465 SER A 1633 REMARK 465 PRO A 1634 REMARK 465 ASN A 1635 REMARK 465 TYR A 1636 REMARK 465 SER A 1637 REMARK 465 PRO A 1638 REMARK 465 THR A 1639 REMARK 465 SER A 1640 REMARK 465 PRO A 1641 REMARK 465 SER A 1642 REMARK 465 TYR A 1643 REMARK 465 SER A 1644 REMARK 465 PRO A 1645 REMARK 465 THR A 1646 REMARK 465 SER A 1647 REMARK 465 PRO A 1648 REMARK 465 SER A 1649 REMARK 465 TYR A 1650 REMARK 465 SER A 1651 REMARK 465 PRO A 1652 REMARK 465 THR A 1653 REMARK 465 SER A 1654 REMARK 465 PRO A 1655 REMARK 465 SER A 1656 REMARK 465 TYR A 1657 REMARK 465 SER A 1658 REMARK 465 PRO A 1659 REMARK 465 THR A 1660 REMARK 465 SER A 1661 REMARK 465 PRO A 1662 REMARK 465 SER A 1663 REMARK 465 TYR A 1664 REMARK 465 SER A 1665 REMARK 465 PRO A 1666 REMARK 465 THR A 1667 REMARK 465 SER A 1668 REMARK 465 PRO A 1669 REMARK 465 SER A 1670 REMARK 465 TYR A 1671 REMARK 465 SER A 1672 REMARK 465 PRO A 1673 REMARK 465 THR A 1674 REMARK 465 SER A 1675 REMARK 465 PRO A 1676 REMARK 465 SER A 1677 REMARK 465 TYR A 1678 REMARK 465 SER A 1679 REMARK 465 PRO A 1680 REMARK 465 THR A 1681 REMARK 465 SER A 1682 REMARK 465 PRO A 1683 REMARK 465 SER A 1684 REMARK 465 TYR A 1685 REMARK 465 SER A 1686 REMARK 465 PRO A 1687 REMARK 465 THR A 1688 REMARK 465 SER A 1689 REMARK 465 PRO A 1690 REMARK 465 SER A 1691 REMARK 465 TYR A 1692 REMARK 465 SER A 1693 REMARK 465 PRO A 1694 REMARK 465 THR A 1695 REMARK 465 SER A 1696 REMARK 465 PRO A 1697 REMARK 465 SER A 1698 REMARK 465 TYR A 1699 REMARK 465 SER A 1700 REMARK 465 PRO A 1701 REMARK 465 THR A 1702 REMARK 465 SER A 1703 REMARK 465 PRO A 1704 REMARK 465 SER A 1705 REMARK 465 TYR A 1706 REMARK 465 SER A 1707 REMARK 465 PRO A 1708 REMARK 465 THR A 1709 REMARK 465 SER A 1710 REMARK 465 PRO A 1711 REMARK 465 SER A 1712 REMARK 465 TYR A 1713 REMARK 465 SER A 1714 REMARK 465 PRO A 1715 REMARK 465 THR A 1716 REMARK 465 SER A 1717 REMARK 465 PRO A 1718 REMARK 465 SER A 1719 REMARK 465 TYR A 1720 REMARK 465 SER A 1721 REMARK 465 PRO A 1722 REMARK 465 THR A 1723 REMARK 465 SER A 1724 REMARK 465 PRO A 1725 REMARK 465 SER A 1726 REMARK 465 TYR A 1727 REMARK 465 SER A 1728 REMARK 465 PRO A 1729 REMARK 465 THR A 1730 REMARK 465 SER A 1731 REMARK 465 PRO A 1732 REMARK 465 SER A 1733 REMARK 465 TYR A 1734 REMARK 465 SER A 1735 REMARK 465 PRO A 1736 REMARK 465 THR A 1737 REMARK 465 SER A 1738 REMARK 465 PRO A 1739 REMARK 465 SER A 1740 REMARK 465 TYR A 1741 REMARK 465 SER A 1742 REMARK 465 PRO A 1743 REMARK 465 THR A 1744 REMARK 465 SER A 1745 REMARK 465 PRO A 1746 REMARK 465 ASN A 1747 REMARK 465 TYR A 1748 REMARK 465 SER A 1749 REMARK 465 PRO A 1750 REMARK 465 THR A 1751 REMARK 465 SER A 1752 REMARK 465 PRO A 1753 REMARK 465 ASN A 1754 REMARK 465 TYR A 1755 REMARK 465 THR A 1756 REMARK 465 PRO A 1757 REMARK 465 THR A 1758 REMARK 465 SER A 1759 REMARK 465 PRO A 1760 REMARK 465 SER A 1761 REMARK 465 TYR A 1762 REMARK 465 SER A 1763 REMARK 465 PRO A 1764 REMARK 465 THR A 1765 REMARK 465 SER A 1766 REMARK 465 PRO A 1767 REMARK 465 SER A 1768 REMARK 465 TYR A 1769 REMARK 465 SER A 1770 REMARK 465 PRO A 1771 REMARK 465 THR A 1772 REMARK 465 SER A 1773 REMARK 465 PRO A 1774 REMARK 465 ASN A 1775 REMARK 465 TYR A 1776 REMARK 465 THR A 1777 REMARK 465 PRO A 1778 REMARK 465 THR A 1779 REMARK 465 SER A 1780 REMARK 465 PRO A 1781 REMARK 465 ASN A 1782 REMARK 465 TYR A 1783 REMARK 465 SER A 1784 REMARK 465 PRO A 1785 REMARK 465 THR A 1786 REMARK 465 SER A 1787 REMARK 465 PRO A 1788 REMARK 465 SER A 1789 REMARK 465 TYR A 1790 REMARK 465 SER A 1791 REMARK 465 PRO A 1792 REMARK 465 THR A 1793 REMARK 465 SER A 1794 REMARK 465 PRO A 1795 REMARK 465 SER A 1796 REMARK 465 TYR A 1797 REMARK 465 SER A 1798 REMARK 465 PRO A 1799 REMARK 465 THR A 1800 REMARK 465 SER A 1801 REMARK 465 PRO A 1802 REMARK 465 SER A 1803 REMARK 465 TYR A 1804 REMARK 465 SER A 1805 REMARK 465 PRO A 1806 REMARK 465 SER A 1807 REMARK 465 SER A 1808 REMARK 465 PRO A 1809 REMARK 465 ARG A 1810 REMARK 465 TYR A 1811 REMARK 465 THR A 1812 REMARK 465 PRO A 1813 REMARK 465 GLN A 1814 REMARK 465 SER A 1815 REMARK 465 PRO A 1816 REMARK 465 THR A 1817 REMARK 465 TYR A 1818 REMARK 465 THR A 1819 REMARK 465 PRO A 1820 REMARK 465 SER A 1821 REMARK 465 SER A 1822 REMARK 465 PRO A 1823 REMARK 465 SER A 1824 REMARK 465 TYR A 1825 REMARK 465 SER A 1826 REMARK 465 PRO A 1827 REMARK 465 SER A 1828 REMARK 465 SER A 1829 REMARK 465 PRO A 1830 REMARK 465 SER A 1831 REMARK 465 TYR A 1832 REMARK 465 SER A 1833 REMARK 465 PRO A 1834 REMARK 465 THR A 1835 REMARK 465 SER A 1836 REMARK 465 PRO A 1837 REMARK 465 LYS A 1838 REMARK 465 TYR A 1839 REMARK 465 THR A 1840 REMARK 465 PRO A 1841 REMARK 465 THR A 1842 REMARK 465 SER A 1843 REMARK 465 PRO A 1844 REMARK 465 SER A 1845 REMARK 465 TYR A 1846 REMARK 465 SER A 1847 REMARK 465 PRO A 1848 REMARK 465 SER A 1849 REMARK 465 SER A 1850 REMARK 465 PRO A 1851 REMARK 465 GLU A 1852 REMARK 465 TYR A 1853 REMARK 465 THR A 1854 REMARK 465 PRO A 1855 REMARK 465 THR A 1856 REMARK 465 SER A 1857 REMARK 465 PRO A 1858 REMARK 465 LYS A 1859 REMARK 465 TYR A 1860 REMARK 465 SER A 1861 REMARK 465 PRO A 1862 REMARK 465 THR A 1863 REMARK 465 SER A 1864 REMARK 465 PRO A 1865 REMARK 465 LYS A 1866 REMARK 465 TYR A 1867 REMARK 465 SER A 1868 REMARK 465 PRO A 1869 REMARK 465 THR A 1870 REMARK 465 SER A 1871 REMARK 465 PRO A 1872 REMARK 465 LYS A 1873 REMARK 465 TYR A 1874 REMARK 465 SER A 1875 REMARK 465 PRO A 1876 REMARK 465 THR A 1877 REMARK 465 SER A 1878 REMARK 465 PRO A 1879 REMARK 465 THR A 1880 REMARK 465 TYR A 1881 REMARK 465 SER A 1882 REMARK 465 PRO A 1883 REMARK 465 THR A 1884 REMARK 465 THR A 1885 REMARK 465 PRO A 1886 REMARK 465 LYS A 1887 REMARK 465 TYR A 1888 REMARK 465 SER A 1889 REMARK 465 PRO A 1890 REMARK 465 THR A 1891 REMARK 465 SER A 1892 REMARK 465 PRO A 1893 REMARK 465 THR A 1894 REMARK 465 TYR A 1895 REMARK 465 SER A 1896 REMARK 465 PRO A 1897 REMARK 465 THR A 1898 REMARK 465 SER A 1899 REMARK 465 PRO A 1900 REMARK 465 VAL A 1901 REMARK 465 TYR A 1902 REMARK 465 THR A 1903 REMARK 465 PRO A 1904 REMARK 465 THR A 1905 REMARK 465 SER A 1906 REMARK 465 PRO A 1907 REMARK 465 LYS A 1908 REMARK 465 TYR A 1909 REMARK 465 SER A 1910 REMARK 465 PRO A 1911 REMARK 465 THR A 1912 REMARK 465 SER A 1913 REMARK 465 PRO A 1914 REMARK 465 THR A 1915 REMARK 465 TYR A 1916 REMARK 465 SER A 1917 REMARK 465 PRO A 1918 REMARK 465 THR A 1919 REMARK 465 SER A 1920 REMARK 465 PRO A 1921 REMARK 465 LYS A 1922 REMARK 465 TYR A 1923 REMARK 465 SER A 1924 REMARK 465 PRO A 1925 REMARK 465 THR A 1926 REMARK 465 SER A 1927 REMARK 465 PRO A 1928 REMARK 465 THR A 1929 REMARK 465 TYR A 1930 REMARK 465 SER A 1931 REMARK 465 PRO A 1932 REMARK 465 THR A 1933 REMARK 465 SER A 1934 REMARK 465 PRO A 1935 REMARK 465 LYS A 1936 REMARK 465 GLY A 1937 REMARK 465 SER A 1938 REMARK 465 THR A 1939 REMARK 465 TYR A 1940 REMARK 465 SER A 1941 REMARK 465 PRO A 1942 REMARK 465 THR A 1943 REMARK 465 SER A 1944 REMARK 465 PRO A 1945 REMARK 465 GLY A 1946 REMARK 465 TYR A 1947 REMARK 465 SER A 1948 REMARK 465 PRO A 1949 REMARK 465 THR A 1950 REMARK 465 SER A 1951 REMARK 465 PRO A 1952 REMARK 465 THR A 1953 REMARK 465 TYR A 1954 REMARK 465 SER A 1955 REMARK 465 LEU A 1956 REMARK 465 THR A 1957 REMARK 465 SER A 1958 REMARK 465 PRO A 1959 REMARK 465 ALA A 1960 REMARK 465 ILE A 1961 REMARK 465 SER A 1962 REMARK 465 PRO A 1963 REMARK 465 ASP A 1964 REMARK 465 ASP A 1965 REMARK 465 SER A 1966 REMARK 465 ASP A 1967 REMARK 465 GLU A 1968 REMARK 465 GLU A 1969 REMARK 465 ASN A 1970 REMARK 465 MET B 1 REMARK 465 TYR B 2 REMARK 465 ASP B 3 REMARK 465 ALA B 4 REMARK 465 ASP B 5 REMARK 465 GLU B 6 REMARK 465 ASP B 7 REMARK 465 MET B 8 REMARK 465 GLN B 9 REMARK 465 TYR B 10 REMARK 465 ASP B 11 REMARK 465 GLU B 12 REMARK 465 ASP B 13 REMARK 465 ASP B 14 REMARK 465 GLU B 70 REMARK 465 ALA B 71 REMARK 465 GLN B 72 REMARK 465 HIS B 73 REMARK 465 ALA B 74 REMARK 465 SER B 75 REMARK 465 GLY B 76 REMARK 465 GLU B 77 REMARK 465 VAL B 78 REMARK 465 GLU B 79 REMARK 465 GLU B 80 REMARK 465 GLY B 244 REMARK 465 GLN B 245 REMARK 465 GLY B 246 REMARK 465 ALA B 247 REMARK 465 LYS B 248 REMARK 465 LYS B 249 REMARK 465 SER B 250 REMARK 465 GLU B 875 REMARK 465 ASN B 876 REMARK 465 GLU B 877 REMARK 465 ASP B 878 REMARK 465 GLU B 879 REMARK 465 LEU B 880 REMARK 465 GLU B 881 REMARK 465 GLY B 882 REMARK 465 THR B 883 REMARK 465 ASN B 884 REMARK 465 ARG B 885 REMARK 465 MET C 1 REMARK 465 ARG C 135 REMARK 465 ASP C 136 REMARK 465 ASN C 137 REMARK 465 ASP C 138 REMARK 465 PRO C 139 REMARK 465 SER C 140 REMARK 465 ASP C 141 REMARK 465 TYR C 142 REMARK 465 VAL C 143 REMARK 465 VAL C 271 REMARK 465 LEU C 272 REMARK 465 THR C 273 REMARK 465 ILE C 274 REMARK 465 ASN C 275 REMARK 465 MET D 1 REMARK 465 ALA D 2 REMARK 465 ALA D 3 REMARK 465 GLY D 4 REMARK 465 GLY D 5 REMARK 465 SER D 6 REMARK 465 ASP D 7 REMARK 465 PRO D 8 REMARK 465 ARG D 9 REMARK 465 ALA D 10 REMARK 465 GLY D 11 REMARK 465 ASP D 12 REMARK 465 VAL D 13 REMARK 465 PHE D 140 REMARK 465 GLN D 141 REMARK 465 TYR D 142 REMARK 465 MET E 1 REMARK 465 MET F 1 REMARK 465 SER F 2 REMARK 465 ASP F 3 REMARK 465 ASN F 4 REMARK 465 GLU F 5 REMARK 465 ASP F 6 REMARK 465 ASN F 7 REMARK 465 PHE F 8 REMARK 465 ASP F 9 REMARK 465 GLY F 10 REMARK 465 ASP F 11 REMARK 465 ASP F 12 REMARK 465 PHE F 13 REMARK 465 ASP F 14 REMARK 465 ASP F 15 REMARK 465 VAL F 16 REMARK 465 GLU F 17 REMARK 465 GLU F 18 REMARK 465 ASP F 19 REMARK 465 GLU F 20 REMARK 465 GLY F 21 REMARK 465 LEU F 22 REMARK 465 ASP F 23 REMARK 465 ASP F 24 REMARK 465 LEU F 25 REMARK 465 GLU F 26 REMARK 465 ASN F 27 REMARK 465 ALA F 28 REMARK 465 GLU F 29 REMARK 465 GLU F 30 REMARK 465 GLU F 31 REMARK 465 GLY F 32 REMARK 465 GLN F 33 REMARK 465 GLU F 34 REMARK 465 ASN F 35 REMARK 465 VAL F 36 REMARK 465 GLU F 37 REMARK 465 ILE F 38 REMARK 465 LEU F 39 REMARK 465 PRO F 40 REMARK 465 SER F 41 REMARK 465 GLY F 42 REMARK 465 GLU F 43 REMARK 465 ARG F 44 REMARK 465 PRO F 45 REMARK 465 SER G 172 REMARK 465 MET H 1 REMARK 465 PHE H 150 REMARK 465 MET I 1 REMARK 465 GLU I 2 REMARK 465 PRO I 3 REMARK 465 ASP I 4 REMARK 465 GLY I 5 REMARK 465 THR I 6 REMARK 465 TYR I 7 REMARK 465 GLU I 8 REMARK 465 ILE K 116 REMARK 465 GLU K 117 REMARK 465 MET L 1 REMARK 465 ASP L 2 REMARK 465 THR L 3 REMARK 465 GLN L 4 REMARK 465 LYS L 5 REMARK 465 ASP L 6 REMARK 465 VAL L 7 REMARK 465 GLN L 8 REMARK 465 PRO L 9 REMARK 465 PRO L 10 REMARK 465 LYS L 11 REMARK 465 GLN L 12 REMARK 465 DC N 1 REMARK 465 DC N 2 REMARK 465 DA N 3 REMARK 465 DT N 4 REMARK 465 DT N 5 REMARK 465 DG N 6 REMARK 465 DA N 7 REMARK 465 DG N 8 REMARK 465 DA N 46 REMARK 465 DG N 47 REMARK 465 DC N 48 REMARK 465 G P 131 REMARK 465 A P 132 REMARK 465 G P 133 REMARK 465 DG T 1 REMARK 465 DC T 2 REMARK 465 DT T 3 REMARK 465 DC T 41 REMARK 465 DT T 42 REMARK 465 DC T 43 REMARK 465 DA T 44 REMARK 465 DA T 45 REMARK 465 DT T 46 REMARK 465 DG T 47 REMARK 465 DG T 48 REMARK 465 MET O 1 REMARK 465 SER O 2 REMARK 465 SER O 3 REMARK 465 HIS O 4 REMARK 465 HIS O 5 REMARK 465 THR O 6 REMARK 465 THR O 7 REMARK 465 PHE O 8 REMARK 465 PRO O 9 REMARK 465 PHE O 10 REMARK 465 ASP O 11 REMARK 465 PRO O 12 REMARK 465 GLU O 13 REMARK 465 ARG O 14 REMARK 465 ARG O 15 REMARK 465 VAL O 16 REMARK 465 ARG O 17 REMARK 465 SER O 18 REMARK 465 THR O 19 REMARK 465 LEU O 20 REMARK 465 LYS O 21 REMARK 465 LYS O 22 REMARK 465 VAL O 23 REMARK 465 PHE O 24 REMARK 465 GLY O 25 REMARK 465 PHE O 26 REMARK 465 ASP O 27 REMARK 465 SER O 28 REMARK 465 PHE O 29 REMARK 465 LYS O 30 REMARK 465 THR O 31 REMARK 465 PRO O 32 REMARK 465 LEU O 33 REMARK 465 GLN O 34 REMARK 465 GLU O 35 REMARK 465 SER O 36 REMARK 465 ALA O 37 REMARK 465 THR O 38 REMARK 465 MET O 39 REMARK 465 ALA O 40 REMARK 465 VAL O 41 REMARK 465 VAL O 42 REMARK 465 LYS O 43 REMARK 465 GLY O 44 REMARK 465 ASN O 45 REMARK 465 LYS O 46 REMARK 465 ASP O 47 REMARK 465 VAL O 48 REMARK 465 PHE O 49 REMARK 465 VAL O 50 REMARK 465 CYS O 51 REMARK 465 MET O 52 REMARK 465 PRO O 53 REMARK 465 THR O 54 REMARK 465 GLY O 55 REMARK 465 ALA O 56 REMARK 465 GLY O 57 REMARK 465 LYS O 58 REMARK 465 SER O 59 REMARK 465 LEU O 60 REMARK 465 CYS O 61 REMARK 465 TYR O 62 REMARK 465 GLN O 63 REMARK 465 LEU O 64 REMARK 465 PRO O 65 REMARK 465 ALA O 66 REMARK 465 LEU O 67 REMARK 465 LEU O 68 REMARK 465 ALA O 69 REMARK 465 LYS O 70 REMARK 465 GLY O 71 REMARK 465 ILE O 72 REMARK 465 THR O 73 REMARK 465 ILE O 74 REMARK 465 VAL O 75 REMARK 465 VAL O 76 REMARK 465 SER O 77 REMARK 465 PRO O 78 REMARK 465 LEU O 79 REMARK 465 ILE O 80 REMARK 465 ALA O 81 REMARK 465 LEU O 82 REMARK 465 ILE O 83 REMARK 465 GLN O 84 REMARK 465 ASP O 85 REMARK 465 GLN O 86 REMARK 465 VAL O 87 REMARK 465 ASP O 88 REMARK 465 HIS O 89 REMARK 465 LEU O 90 REMARK 465 LEU O 91 REMARK 465 THR O 92 REMARK 465 LEU O 93 REMARK 465 LYS O 94 REMARK 465 VAL O 95 REMARK 465 ARG O 96 REMARK 465 VAL O 97 REMARK 465 SER O 98 REMARK 465 SER O 99 REMARK 465 LEU O 100 REMARK 465 ASN O 101 REMARK 465 SER O 102 REMARK 465 LYS O 103 REMARK 465 LEU O 104 REMARK 465 SER O 105 REMARK 465 ALA O 106 REMARK 465 GLN O 107 REMARK 465 GLU O 108 REMARK 465 ARG O 109 REMARK 465 LYS O 110 REMARK 465 GLU O 111 REMARK 465 LEU O 112 REMARK 465 LEU O 113 REMARK 465 ALA O 114 REMARK 465 ASP O 115 REMARK 465 LEU O 116 REMARK 465 GLU O 117 REMARK 465 ARG O 118 REMARK 465 GLU O 119 REMARK 465 LYS O 120 REMARK 465 PRO O 121 REMARK 465 GLN O 122 REMARK 465 THR O 123 REMARK 465 LYS O 124 REMARK 465 ILE O 125 REMARK 465 LEU O 126 REMARK 465 TYR O 127 REMARK 465 ILE O 128 REMARK 465 THR O 129 REMARK 465 PRO O 130 REMARK 465 GLU O 131 REMARK 465 MET O 132 REMARK 465 ALA O 133 REMARK 465 ALA O 134 REMARK 465 SER O 135 REMARK 465 SER O 136 REMARK 465 SER O 137 REMARK 465 PHE O 138 REMARK 465 GLN O 139 REMARK 465 PRO O 140 REMARK 465 THR O 141 REMARK 465 LEU O 142 REMARK 465 ASN O 143 REMARK 465 SER O 144 REMARK 465 LEU O 145 REMARK 465 VAL O 146 REMARK 465 SER O 147 REMARK 465 ARG O 148 REMARK 465 HIS O 149 REMARK 465 LEU O 150 REMARK 465 LEU O 151 REMARK 465 SER O 152 REMARK 465 TYR O 153 REMARK 465 LEU O 154 REMARK 465 VAL O 155 REMARK 465 VAL O 156 REMARK 465 ASP O 157 REMARK 465 GLU O 158 REMARK 465 ALA O 159 REMARK 465 HIS O 160 REMARK 465 CYS O 161 REMARK 465 VAL O 162 REMARK 465 SER O 163 REMARK 465 GLN O 164 REMARK 465 TRP O 165 REMARK 465 GLY O 166 REMARK 465 HIS O 167 REMARK 465 ASP O 168 REMARK 465 PHE O 169 REMARK 465 ARG O 170 REMARK 465 PRO O 171 REMARK 465 ASP O 172 REMARK 465 TYR O 173 REMARK 465 LEU O 174 REMARK 465 ARG O 175 REMARK 465 LEU O 176 REMARK 465 GLY O 177 REMARK 465 ALA O 178 REMARK 465 LEU O 179 REMARK 465 ARG O 180 REMARK 465 SER O 181 REMARK 465 ARG O 182 REMARK 465 LEU O 183 REMARK 465 GLY O 184 REMARK 465 HIS O 185 REMARK 465 ALA O 186 REMARK 465 PRO O 187 REMARK 465 CYS O 188 REMARK 465 VAL O 189 REMARK 465 ALA O 190 REMARK 465 LEU O 191 REMARK 465 THR O 192 REMARK 465 ALA O 193 REMARK 465 THR O 194 REMARK 465 ALA O 195 REMARK 465 THR O 196 REMARK 465 PRO O 197 REMARK 465 GLN O 198 REMARK 465 VAL O 199 REMARK 465 GLN O 200 REMARK 465 GLU O 201 REMARK 465 ASP O 202 REMARK 465 VAL O 203 REMARK 465 PHE O 204 REMARK 465 ALA O 205 REMARK 465 ALA O 206 REMARK 465 LEU O 207 REMARK 465 HIS O 208 REMARK 465 LEU O 209 REMARK 465 LYS O 210 REMARK 465 LYS O 211 REMARK 465 PRO O 212 REMARK 465 VAL O 213 REMARK 465 ALA O 214 REMARK 465 ILE O 215 REMARK 465 PHE O 216 REMARK 465 LYS O 217 REMARK 465 THR O 218 REMARK 465 PRO O 219 REMARK 465 CYS O 220 REMARK 465 PHE O 221 REMARK 465 ARG O 222 REMARK 465 ALA O 223 REMARK 465 ASN O 224 REMARK 465 LEU O 225 REMARK 465 PHE O 226 REMARK 465 TYR O 227 REMARK 465 ASP O 228 REMARK 465 VAL O 229 REMARK 465 GLN O 230 REMARK 465 PHE O 231 REMARK 465 LYS O 232 REMARK 465 GLU O 233 REMARK 465 LEU O 234 REMARK 465 ILE O 235 REMARK 465 SER O 236 REMARK 465 ASP O 237 REMARK 465 PRO O 238 REMARK 465 TYR O 239 REMARK 465 GLY O 240 REMARK 465 ASN O 241 REMARK 465 LEU O 242 REMARK 465 LYS O 243 REMARK 465 ASP O 244 REMARK 465 PHE O 245 REMARK 465 CYS O 246 REMARK 465 LEU O 247 REMARK 465 LYS O 248 REMARK 465 ALA O 249 REMARK 465 LEU O 250 REMARK 465 GLY O 251 REMARK 465 GLN O 252 REMARK 465 GLU O 253 REMARK 465 ALA O 254 REMARK 465 ASP O 255 REMARK 465 LYS O 256 REMARK 465 GLY O 257 REMARK 465 LEU O 258 REMARK 465 SER O 259 REMARK 465 GLY O 260 REMARK 465 CYS O 261 REMARK 465 GLY O 262 REMARK 465 ILE O 263 REMARK 465 VAL O 264 REMARK 465 TYR O 265 REMARK 465 CYS O 266 REMARK 465 ARG O 267 REMARK 465 THR O 268 REMARK 465 ARG O 269 REMARK 465 GLU O 270 REMARK 465 ALA O 271 REMARK 465 CYS O 272 REMARK 465 GLU O 273 REMARK 465 GLN O 274 REMARK 465 LEU O 275 REMARK 465 ALA O 276 REMARK 465 ILE O 277 REMARK 465 GLU O 278 REMARK 465 LEU O 279 REMARK 465 SER O 280 REMARK 465 CYS O 281 REMARK 465 ARG O 282 REMARK 465 GLY O 283 REMARK 465 VAL O 284 REMARK 465 ASN O 285 REMARK 465 ALA O 286 REMARK 465 LYS O 287 REMARK 465 ALA O 288 REMARK 465 TYR O 289 REMARK 465 HIS O 290 REMARK 465 ALA O 291 REMARK 465 GLY O 292 REMARK 465 LEU O 293 REMARK 465 LYS O 294 REMARK 465 ALA O 295 REMARK 465 SER O 296 REMARK 465 GLU O 297 REMARK 465 ARG O 298 REMARK 465 THR O 299 REMARK 465 LEU O 300 REMARK 465 VAL O 301 REMARK 465 GLN O 302 REMARK 465 ASN O 303 REMARK 465 ASP O 304 REMARK 465 TRP O 305 REMARK 465 MET O 306 REMARK 465 GLU O 307 REMARK 465 GLU O 308 REMARK 465 LYS O 309 REMARK 465 VAL O 310 REMARK 465 PRO O 311 REMARK 465 VAL O 312 REMARK 465 ILE O 313 REMARK 465 VAL O 314 REMARK 465 ALA O 315 REMARK 465 THR O 316 REMARK 465 ILE O 317 REMARK 465 SER O 318 REMARK 465 PHE O 319 REMARK 465 GLY O 320 REMARK 465 MET O 321 REMARK 465 GLY O 322 REMARK 465 VAL O 323 REMARK 465 ASP O 324 REMARK 465 LYS O 325 REMARK 465 ALA O 326 REMARK 465 ASN O 327 REMARK 465 VAL O 328 REMARK 465 ARG O 329 REMARK 465 PHE O 330 REMARK 465 VAL O 331 REMARK 465 ALA O 332 REMARK 465 HIS O 333 REMARK 465 TRP O 334 REMARK 465 ASN O 335 REMARK 465 ILE O 336 REMARK 465 ALA O 337 REMARK 465 LYS O 338 REMARK 465 SER O 339 REMARK 465 MET O 340 REMARK 465 ALA O 341 REMARK 465 GLY O 342 REMARK 465 TYR O 343 REMARK 465 TYR O 344 REMARK 465 GLN O 345 REMARK 465 GLU O 346 REMARK 465 SER O 347 REMARK 465 GLY O 348 REMARK 465 ARG O 349 REMARK 465 ALA O 350 REMARK 465 GLY O 351 REMARK 465 ARG O 352 REMARK 465 ASP O 353 REMARK 465 GLY O 354 REMARK 465 LYS O 355 REMARK 465 PRO O 356 REMARK 465 SER O 357 REMARK 465 TRP O 358 REMARK 465 CYS O 359 REMARK 465 ARG O 360 REMARK 465 LEU O 361 REMARK 465 TYR O 362 REMARK 465 TYR O 363 REMARK 465 SER O 364 REMARK 465 ARG O 365 REMARK 465 ASN O 366 REMARK 465 ASP O 367 REMARK 465 ARG O 368 REMARK 465 ASP O 369 REMARK 465 GLN O 370 REMARK 465 VAL O 371 REMARK 465 SER O 372 REMARK 465 PHE O 373 REMARK 465 LEU O 374 REMARK 465 ILE O 375 REMARK 465 ARG O 376 REMARK 465 LYS O 377 REMARK 465 GLU O 378 REMARK 465 VAL O 379 REMARK 465 ALA O 380 REMARK 465 LYS O 381 REMARK 465 LEU O 382 REMARK 465 GLN O 383 REMARK 465 GLU O 384 REMARK 465 LYS O 385 REMARK 465 ARG O 386 REMARK 465 GLY O 387 REMARK 465 ASN O 388 REMARK 465 LYS O 389 REMARK 465 ALA O 390 REMARK 465 SER O 391 REMARK 465 ASP O 392 REMARK 465 LYS O 393 REMARK 465 ALA O 394 REMARK 465 THR O 395 REMARK 465 ILE O 396 REMARK 465 MET O 397 REMARK 465 ALA O 398 REMARK 465 PHE O 399 REMARK 465 ASP O 400 REMARK 465 ALA O 401 REMARK 465 LEU O 402 REMARK 465 VAL O 403 REMARK 465 THR O 404 REMARK 465 PHE O 405 REMARK 465 CYS O 406 REMARK 465 GLU O 407 REMARK 465 GLU O 408 REMARK 465 LEU O 409 REMARK 465 GLY O 410 REMARK 465 CYS O 411 REMARK 465 ARG O 412 REMARK 465 HIS O 413 REMARK 465 ALA O 414 REMARK 465 ALA O 415 REMARK 465 ILE O 416 REMARK 465 ALA O 417 REMARK 465 LYS O 418 REMARK 465 TYR O 419 REMARK 465 PHE O 420 REMARK 465 GLY O 421 REMARK 465 ASP O 422 REMARK 465 ALA O 423 REMARK 465 LEU O 424 REMARK 465 PRO O 425 REMARK 465 ALA O 426 REMARK 465 CYS O 427 REMARK 465 ALA O 428 REMARK 465 LYS O 429 REMARK 465 GLY O 430 REMARK 465 CYS O 431 REMARK 465 ASP O 432 REMARK 465 HIS O 433 REMARK 465 CYS O 434 REMARK 465 GLN O 435 REMARK 465 ASN O 436 REMARK 465 PRO O 437 REMARK 465 THR O 438 REMARK 465 ALA O 439 REMARK 465 VAL O 440 REMARK 465 ARG O 441 REMARK 465 ARG O 442 REMARK 465 ARG O 443 REMARK 465 LEU O 444 REMARK 465 GLU O 445 REMARK 465 ALA O 446 REMARK 465 LEU O 447 REMARK 465 GLU O 448 REMARK 465 ARG O 449 REMARK 465 SER O 450 REMARK 465 SER O 451 REMARK 465 SER O 452 REMARK 465 TRP O 453 REMARK 465 SER O 454 REMARK 465 LYS O 455 REMARK 465 THR O 456 REMARK 465 CYS O 457 REMARK 465 ILE O 458 REMARK 465 GLY O 459 REMARK 465 PRO O 460 REMARK 465 SER O 461 REMARK 465 GLN O 462 REMARK 465 GLY O 463 REMARK 465 ASN O 464 REMARK 465 GLY O 465 REMARK 465 PHE O 466 REMARK 465 ASP O 467 REMARK 465 PRO O 468 REMARK 465 GLU O 469 REMARK 465 LEU O 470 REMARK 465 TYR O 471 REMARK 465 GLU O 472 REMARK 465 GLY O 473 REMARK 465 GLY O 474 REMARK 465 ARG O 475 REMARK 465 LYS O 476 REMARK 465 GLY O 477 REMARK 465 TYR O 478 REMARK 465 GLY O 479 REMARK 465 ASP O 480 REMARK 465 PHE O 481 REMARK 465 SER O 482 REMARK 465 ARG O 483 REMARK 465 TYR O 484 REMARK 465 ASP O 485 REMARK 465 GLU O 486 REMARK 465 GLY O 487 REMARK 465 SER O 488 REMARK 465 GLY O 489 REMARK 465 GLY O 490 REMARK 465 SER O 491 REMARK 465 GLY O 492 REMARK 465 ASP O 493 REMARK 465 GLU O 494 REMARK 465 GLY O 495 REMARK 465 GLN O 616 REMARK 465 PRO O 617 REMARK 465 TYR O 618 REMARK 465 ASP O 619 REMARK 465 MET O 620 REMARK 465 GLY O 621 REMARK 465 GLY O 622 REMARK 465 SER O 623 REMARK 465 ALA O 624 REMARK 465 LYS O 625 REMARK 465 SER O 626 REMARK 465 CYS O 627 REMARK 465 SER O 628 REMARK 465 ALA O 629 REMARK 465 GLN O 630 REMARK 465 ALA O 631 REMARK 465 GLU O 632 REMARK 465 PRO O 633 REMARK 465 PRO O 634 REMARK 465 GLU O 635 REMARK 465 PRO O 636 REMARK 465 ASN O 637 REMARK 465 GLU O 638 REMARK 465 TYR O 639 REMARK 465 ASP O 640 REMARK 465 ILE O 641 REMARK 465 PRO O 642 REMARK 465 PRO O 643 REMARK 465 ALA O 644 REMARK 465 SER O 645 REMARK 465 HIS O 646 REMARK 465 VAL O 647 REMARK 465 TYR O 648 REMARK 465 SER O 649 REMARK 465 LEU O 650 REMARK 465 LYS O 651 REMARK 465 PRO O 652 REMARK 465 LYS O 653 REMARK 465 ARG O 654 REMARK 465 VAL O 655 REMARK 465 GLY O 656 REMARK 465 ALA O 657 REMARK 465 GLY O 658 REMARK 465 PHE O 659 REMARK 465 PRO O 660 REMARK 465 LYS O 661 REMARK 465 GLY O 662 REMARK 465 SER O 663 REMARK 465 CYS O 664 REMARK 465 PRO O 665 REMARK 465 PHE O 666 REMARK 465 GLN O 667 REMARK 465 THR O 668 REMARK 465 ALA O 669 REMARK 465 THR O 670 REMARK 465 GLU O 671 REMARK 465 LEU O 672 REMARK 465 MET O 673 REMARK 465 GLU O 674 REMARK 465 THR O 675 REMARK 465 THR O 676 REMARK 465 ARG O 677 REMARK 465 ILE O 678 REMARK 465 ARG O 679 REMARK 465 GLU O 680 REMARK 465 GLN O 681 REMARK 465 ALA O 682 REMARK 465 PRO O 683 REMARK 465 GLN O 684 REMARK 465 PRO O 685 REMARK 465 GLU O 686 REMARK 465 ARG O 687 REMARK 465 GLY O 688 REMARK 465 GLY O 689 REMARK 465 GLU O 690 REMARK 465 HIS O 691 REMARK 465 GLU O 692 REMARK 465 PRO O 693 REMARK 465 PRO O 694 REMARK 465 SER O 695 REMARK 465 ARG O 696 REMARK 465 PRO O 697 REMARK 465 CYS O 698 REMARK 465 GLY O 699 REMARK 465 LEU O 700 REMARK 465 LEU O 701 REMARK 465 ASP O 702 REMARK 465 GLU O 703 REMARK 465 ASP O 704 REMARK 465 GLY O 705 REMARK 465 SER O 706 REMARK 465 GLU O 707 REMARK 465 PRO O 708 REMARK 465 LEU O 709 REMARK 465 PRO O 710 REMARK 465 GLY O 711 REMARK 465 PRO O 712 REMARK 465 ARG O 713 REMARK 465 GLY O 714 REMARK 465 GLU O 715 REMARK 465 VAL O 716 REMARK 465 PRO O 717 REMARK 465 GLY O 718 REMARK 465 GLY O 719 REMARK 465 SER O 720 REMARK 465 ALA O 721 REMARK 465 HIS O 722 REMARK 465 TYR O 723 REMARK 465 GLY O 724 REMARK 465 GLY O 725 REMARK 465 PRO O 726 REMARK 465 SER O 727 REMARK 465 PRO O 728 REMARK 465 GLU O 729 REMARK 465 LYS O 730 REMARK 465 LYS O 731 REMARK 465 ALA O 732 REMARK 465 LYS O 733 REMARK 465 SER O 734 REMARK 465 SER O 735 REMARK 465 SER O 736 REMARK 465 GLY O 737 REMARK 465 GLY O 738 REMARK 465 SER O 739 REMARK 465 SER O 740 REMARK 465 LEU O 741 REMARK 465 ALA O 742 REMARK 465 LYS O 743 REMARK 465 GLY O 744 REMARK 465 ARG O 745 REMARK 465 ALA O 746 REMARK 465 SER O 747 REMARK 465 LYS O 748 REMARK 465 LYS O 749 REMARK 465 GLN O 750 REMARK 465 GLN O 751 REMARK 465 LEU O 752 REMARK 465 LEU O 753 REMARK 465 ALA O 754 REMARK 465 THR O 755 REMARK 465 ALA O 756 REMARK 465 ALA O 757 REMARK 465 HIS O 758 REMARK 465 LYS O 759 REMARK 465 ASP O 760 REMARK 465 SER O 761 REMARK 465 GLN O 762 REMARK 465 SER O 763 REMARK 465 ILE O 764 REMARK 465 ALA O 765 REMARK 465 ARG O 766 REMARK 465 PHE O 767 REMARK 465 PHE O 768 REMARK 465 CYS O 769 REMARK 465 ARG O 770 REMARK 465 ARG O 771 REMARK 465 VAL O 772 REMARK 465 GLU O 773 REMARK 465 SER O 774 REMARK 465 PRO O 775 REMARK 465 ALA O 776 REMARK 465 LEU O 777 REMARK 465 LEU O 778 REMARK 465 ALA O 779 REMARK 465 SER O 780 REMARK 465 ALA O 781 REMARK 465 PRO O 782 REMARK 465 GLU O 783 REMARK 465 ALA O 784 REMARK 465 GLU O 785 REMARK 465 GLY O 786 REMARK 465 ALA O 787 REMARK 465 CYS O 788 REMARK 465 PRO O 789 REMARK 465 SER O 790 REMARK 465 CYS O 791 REMARK 465 GLU O 792 REMARK 465 GLY O 793 REMARK 465 VAL O 794 REMARK 465 GLN O 795 REMARK 465 GLY O 796 REMARK 465 PRO O 797 REMARK 465 PRO O 798 REMARK 465 MET O 799 REMARK 465 ALA O 800 REMARK 465 PRO O 801 REMARK 465 GLU O 802 REMARK 465 LYS O 803 REMARK 465 TYR O 804 REMARK 465 THR O 805 REMARK 465 GLY O 806 REMARK 465 GLU O 807 REMARK 465 GLU O 808 REMARK 465 ASP O 809 REMARK 465 GLY O 810 REMARK 465 ALA O 811 REMARK 465 GLY O 812 REMARK 465 GLY O 813 REMARK 465 HIS O 814 REMARK 465 SER O 815 REMARK 465 PRO O 816 REMARK 465 ALA O 817 REMARK 465 PRO O 818 REMARK 465 PRO O 819 REMARK 465 GLN O 820 REMARK 465 THR O 821 REMARK 465 GLU O 822 REMARK 465 GLU O 823 REMARK 465 CYS O 824 REMARK 465 LEU O 825 REMARK 465 ARG O 826 REMARK 465 GLU O 827 REMARK 465 ARG O 828 REMARK 465 PRO O 829 REMARK 465 SER O 830 REMARK 465 THR O 831 REMARK 465 CYS O 832 REMARK 465 PRO O 833 REMARK 465 PRO O 834 REMARK 465 ARG O 835 REMARK 465 ASP O 836 REMARK 465 GLN O 837 REMARK 465 GLY O 838 REMARK 465 THR O 839 REMARK 465 PRO O 840 REMARK 465 GLU O 841 REMARK 465 VAL O 842 REMARK 465 GLN O 843 REMARK 465 PRO O 844 REMARK 465 THR O 845 REMARK 465 PRO O 846 REMARK 465 ALA O 847 REMARK 465 LYS O 848 REMARK 465 ASP O 849 REMARK 465 THR O 850 REMARK 465 TRP O 851 REMARK 465 LYS O 852 REMARK 465 GLY O 853 REMARK 465 LYS O 854 REMARK 465 ARG O 855 REMARK 465 PRO O 856 REMARK 465 ARG O 857 REMARK 465 SER O 858 REMARK 465 GLN O 859 REMARK 465 GLN O 860 REMARK 465 GLU O 861 REMARK 465 ASN O 862 REMARK 465 PRO O 863 REMARK 465 GLU O 864 REMARK 465 SER O 865 REMARK 465 GLN O 866 REMARK 465 PRO O 867 REMARK 465 GLN O 868 REMARK 465 LYS O 869 REMARK 465 ARG O 870 REMARK 465 PRO O 871 REMARK 465 ARG O 872 REMARK 465 PRO O 873 REMARK 465 SER O 874 REMARK 465 ALA O 875 REMARK 465 LYS O 876 REMARK 465 PRO O 877 REMARK 465 SER O 878 REMARK 465 VAL O 879 REMARK 465 VAL O 880 REMARK 465 ALA O 881 REMARK 465 GLU O 882 REMARK 465 VAL O 883 REMARK 465 LYS O 884 REMARK 465 GLY O 885 REMARK 465 SER O 886 REMARK 465 VAL O 887 REMARK 465 SER O 888 REMARK 465 ALA O 889 REMARK 465 SER O 890 REMARK 465 GLU O 891 REMARK 465 GLN O 892 REMARK 465 GLY O 893 REMARK 465 THR O 894 REMARK 465 LEU O 895 REMARK 465 ASN O 896 REMARK 465 PRO O 897 REMARK 465 THR O 898 REMARK 465 ALA O 899 REMARK 465 GLN O 900 REMARK 465 ASP O 901 REMARK 465 PRO O 902 REMARK 465 PHE O 903 REMARK 465 GLN O 904 REMARK 465 LEU O 905 REMARK 465 SER O 906 REMARK 465 ALA O 907 REMARK 465 PRO O 908 REMARK 465 GLY O 909 REMARK 465 VAL O 910 REMARK 465 SER O 911 REMARK 465 LEU O 912 REMARK 465 LYS O 913 REMARK 465 GLU O 914 REMARK 465 ALA O 915 REMARK 465 ALA O 916 REMARK 465 ASN O 917 REMARK 465 VAL O 918 REMARK 465 VAL O 919 REMARK 465 VAL O 920 REMARK 465 LYS O 921 REMARK 465 CYS O 922 REMARK 465 LEU O 923 REMARK 465 THR O 924 REMARK 465 PRO O 925 REMARK 465 PHE O 926 REMARK 465 TYR O 927 REMARK 465 LYS O 928 REMARK 465 GLU O 929 REMARK 465 GLY O 930 REMARK 465 LYS O 931 REMARK 465 PHE O 932 REMARK 465 ALA O 933 REMARK 465 SER O 934 REMARK 465 LYS O 935 REMARK 465 GLU O 936 REMARK 465 LEU O 937 REMARK 465 PHE O 938 REMARK 465 LYS O 939 REMARK 465 GLY O 940 REMARK 465 PHE O 941 REMARK 465 ALA O 942 REMARK 465 ARG O 943 REMARK 465 HIS O 944 REMARK 465 LEU O 945 REMARK 465 SER O 946 REMARK 465 HIS O 947 REMARK 465 LEU O 948 REMARK 465 LEU O 949 REMARK 465 THR O 950 REMARK 465 GLN O 951 REMARK 465 LYS O 952 REMARK 465 THR O 953 REMARK 465 SER O 954 REMARK 465 PRO O 955 REMARK 465 GLY O 956 REMARK 465 ARG O 957 REMARK 465 SER O 958 REMARK 465 VAL O 959 REMARK 465 LYS O 960 REMARK 465 GLU O 961 REMARK 465 GLU O 962 REMARK 465 ALA O 963 REMARK 465 GLN O 964 REMARK 465 ASN O 965 REMARK 465 LEU O 966 REMARK 465 ILE O 967 REMARK 465 ARG O 968 REMARK 465 HIS O 969 REMARK 465 PHE O 970 REMARK 465 PHE O 971 REMARK 465 HIS O 972 REMARK 465 GLY O 973 REMARK 465 ARG O 974 REMARK 465 ALA O 975 REMARK 465 ARG O 976 REMARK 465 CYS O 977 REMARK 465 GLU O 978 REMARK 465 SER O 979 REMARK 465 GLU O 980 REMARK 465 ALA O 981 REMARK 465 ASP O 982 REMARK 465 TRP O 983 REMARK 465 HIS O 984 REMARK 465 GLY O 985 REMARK 465 LEU O 986 REMARK 465 CYS O 987 REMARK 465 GLY O 988 REMARK 465 PRO O 989 REMARK 465 GLN O 990 REMARK 465 ARG O 991 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG1 THR A 1314 OD1 ASN A 1316 1.95 REMARK 500 OG1 THR E 29 OD1 ASP E 31 1.99 REMARK 500 OH TYR D 67 OE2 GLU G 100 2.00 REMARK 500 OH TYR A 763 OD2 ASP H 23 2.09 REMARK 500 OH TYR A 413 O MET A 450 2.09 REMARK 500 OG1 THR B 910 O ARG L 42 2.09 REMARK 500 OH TYR B 215 OE1 GLU B 266 2.10 REMARK 500 O ASP A 1353 OG1 THR A 1357 2.11 REMARK 500 NH2 ARG B 591 OE2 GLU B 663 2.12 REMARK 500 OE2 GLU A 197 NZ LYS A 308 2.12 REMARK 500 OD2 ASP A 814 OH TYR B 689 2.12 REMARK 500 OE2 GLU A 613 OG SER A 622 2.12 REMARK 500 OD2 ASP A 1189 NE ARG A 1258 2.13 REMARK 500 ND2 ASN C 190 O THR C 195 2.13 REMARK 500 OE1 GLU A 893 OG SER E 197 2.13 REMARK 500 O ASP D 133 OG1 THR D 136 2.15 REMARK 500 OH TYR H 48 OE1 GLU H 89 2.15 REMARK 500 OD2 ASP H 67 OG1 THR H 69 2.15 REMARK 500 OD1 ASP A 941 ND2 ASN A 945 2.15 REMARK 500 O GLU H 136 OG SER H 139 2.16 REMARK 500 NE2 GLN E 30 OD1 ASP E 34 2.16 REMARK 500 NH1 ARG B 274 O ILE B 311 2.17 REMARK 500 OD1 ASP A 540 OG SER B 784 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER A 209 112.22 -160.31 REMARK 500 PRO A 257 -178.39 -67.60 REMARK 500 LYS A 331 141.32 -171.25 REMARK 500 THR A 365 -179.93 -171.45 REMARK 500 PRO A 414 69.35 -67.76 REMARK 500 PHE A 496 34.67 -98.70 REMARK 500 ASP A 497 50.49 -93.34 REMARK 500 ASN A 531 58.26 39.18 REMARK 500 GLN A 539 -129.19 61.73 REMARK 500 ARG A 583 77.89 53.77 REMARK 500 LYS A 627 68.11 61.05 REMARK 500 CYS A 641 -168.41 -161.73 REMARK 500 ALA A 786 -169.82 -102.11 REMARK 500 ARG A 797 170.30 -58.32 REMARK 500 ALA A 877 -2.58 79.68 REMARK 500 GLU A 893 -6.64 74.08 REMARK 500 LEU A1049 53.76 -92.27 REMARK 500 LEU A1144 -63.91 -94.31 REMARK 500 ASN A1172 145.49 -171.29 REMARK 500 ASP A1423 51.79 -93.12 REMARK 500 ASP B 212 51.98 -91.56 REMARK 500 GLU B 220 142.14 -170.47 REMARK 500 PRO B 231 -179.56 -67.58 REMARK 500 ILE B 252 -62.01 -122.11 REMARK 500 SER B 354 -179.60 -69.36 REMARK 500 GLU B 609 -169.71 -76.24 REMARK 500 ASN B 739 35.58 -99.36 REMARK 500 THR B 786 -6.05 73.90 REMARK 500 GLU B 791 60.19 61.84 REMARK 500 THR B 888 9.39 56.96 REMARK 500 ASN B 912 -167.89 -79.44 REMARK 500 PHE B1002 64.94 -101.11 REMARK 500 ILE B1069 -60.52 -92.92 REMARK 500 PRO B1074 160.94 -49.63 REMARK 500 PHE B1108 -55.93 -120.16 REMARK 500 ASP B1112 70.77 -160.47 REMARK 500 SER B1166 35.41 70.08 REMARK 500 TYR C 3 -169.64 -126.47 REMARK 500 GLU C 41 32.64 -142.99 REMARK 500 SER C 75 32.36 -140.60 REMARK 500 ALA D 29 -169.76 -79.60 REMARK 500 CYS D 104 65.55 39.10 REMARK 500 ARG G 78 81.03 -154.93 REMARK 500 GLU G 133 -4.08 69.34 REMARK 500 SER I 51 -5.65 77.43 REMARK 500 GLU L 21 -60.16 -96.56 REMARK 500 ARG L 31 -4.65 71.45 REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN A2001 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS A 71 SG REMARK 620 2 CYS A 74 SG 107.7 REMARK 620 3 CYS A 81 SG 102.8 100.4 REMARK 620 4 HIS A 84 NE2 107.1 96.7 138.9 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN A2002 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS A 111 SG REMARK 620 2 CYS A 154 SG 106.3 REMARK 620 3 CYS A 184 SG 108.2 125.2 REMARK 620 N 1 2 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 MG A2003 MG REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP A 495 OD1 REMARK 620 2 ASP A 495 OD2 47.3 REMARK 620 3 ASP A 497 OD1 92.9 87.0 REMARK 620 4 ASP A 497 OD2 102.2 64.2 47.2 REMARK 620 5 ASP A 499 OD1 99.2 146.5 95.8 137.5 REMARK 620 6 U P 145 O3' 150.9 138.4 114.5 103.6 69.9 REMARK 620 N 1 2 3 4 5 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN B1201 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS B1119 SG REMARK 620 2 CYS B1122 SG 111.1 REMARK 620 3 CYS B1137 SG 116.0 93.3 REMARK 620 4 CYS B1140 SG 116.6 93.1 120.0 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN C 301 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS C 88 SG REMARK 620 2 CYS C 90 SG 109.4 REMARK 620 3 CYS C 94 SG 94.1 112.7 REMARK 620 4 CYS C 97 SG 115.2 106.7 118.4 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN I 201 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS I 17 SG REMARK 620 2 CYS I 20 SG 95.3 REMARK 620 3 CYS I 39 SG 108.4 79.0 REMARK 620 N 1 2 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN I 202 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS I 86 SG REMARK 620 2 CYS I 89 SG 90.0 REMARK 620 3 CYS I 114 SG 96.2 119.0 REMARK 620 4 CYS I 119 SG 124.6 112.6 112.6 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN J 101 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS J 7 SG REMARK 620 2 CYS J 10 SG 107.7 REMARK 620 3 CYS J 44 SG 114.6 119.1 REMARK 620 4 CYS J 45 SG 114.0 91.8 107.6 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN L 101 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS L 19 SG REMARK 620 2 CYS L 22 SG 110.5 REMARK 620 3 CYS L 36 SG 105.6 110.7 REMARK 620 4 CYS L 39 SG 104.5 119.3 105.3 REMARK 620 N 1 2 3 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-52440 RELATED DB: EMDB REMARK 900 STRUCTURE OF THE TRANSCRIBING POL II-RECQL5 COMPLEX DBREF1 9HVO A 1 1970 UNP A0A8D1DPV6_PIG DBREF2 9HVO A A0A8D1DPV6 1 1970 DBREF1 9HVO B 1 1174 UNP A0A0B8RVL1_PIG DBREF2 9HVO B A0A0B8RVL1 1 1174 DBREF 9HVO C 1 275 UNP I3LCH3 I3LCH3_PIG 1 275 DBREF1 9HVO D 1 142 UNP A0A4X1VM56_PIG DBREF2 9HVO D A0A4X1VM56 1 142 DBREF 9HVO E 1 210 UNP I3LSI7 I3LSI7_PIG 1 210 DBREF1 9HVO F 1 127 UNP A0A4X1VEK9_PIG DBREF2 9HVO F A0A4X1VEK9 1 127 DBREF1 9HVO G 1 172 UNP A0A4X1VKG7_PIG DBREF2 9HVO G A0A4X1VKG7 1 172 DBREF 9HVO H 1 150 UNP I3LCB2 I3LCB2_PIG 1 150 DBREF 9HVO I 1 125 UNP P60899 RPB9_PIG 1 125 DBREF1 9HVO J 1 67 UNP A0A4X1VYD0_PIG DBREF2 9HVO J A0A4X1VYD0 1 67 DBREF 9HVO K 1 117 UNP F1RKE4 F1RKE4_PIG 1 117 DBREF1 9HVO L 1 58 UNP A0A4X1TRS6_PIG DBREF2 9HVO L A0A4X1TRS6 1 58 DBREF 9HVO N 1 48 PDB 9HVO 9HVO 1 48 DBREF 9HVO P 131 145 PDB 9HVO 9HVO 131 145 DBREF 9HVO T 1 48 PDB 9HVO 9HVO 1 48 DBREF 9HVO O 1 991 UNP O94762 RECQ5_HUMAN 1 991 SEQRES 1 A 1970 MET HIS GLY GLY GLY PRO PRO SER GLY ASP SER ALA CYS SEQRES 2 A 1970 PRO LEU ARG THR ILE LYS ARG VAL GLN PHE GLY VAL LEU SEQRES 3 A 1970 SER PRO ASP GLU LEU LYS ARG MET SER VAL THR GLU GLY SEQRES 4 A 1970 GLY ILE LYS TYR PRO GLU THR THR GLU GLY GLY ARG PRO SEQRES 5 A 1970 LYS LEU GLY GLY LEU MET ASP PRO ARG GLN GLY VAL ILE SEQRES 6 A 1970 GLU ARG THR GLY ARG CYS GLN THR CYS ALA GLY ASN MET SEQRES 7 A 1970 THR GLU CYS PRO GLY HIS PHE GLY HIS ILE GLU LEU ALA SEQRES 8 A 1970 LYS PRO VAL PHE HIS VAL GLY PHE LEU VAL LYS THR MET SEQRES 9 A 1970 LYS VAL LEU ARG CYS VAL CYS PHE PHE CYS SER LYS LEU SEQRES 10 A 1970 LEU VAL ASP SER ASN ASN PRO LYS ILE LYS ASP ILE LEU SEQRES 11 A 1970 ALA LYS SER LYS GLY GLN PRO LYS LYS ARG LEU THR HIS SEQRES 12 A 1970 VAL TYR ASP LEU CYS LYS GLY LYS ASN ILE CYS GLU GLY SEQRES 13 A 1970 GLY GLU GLU MET ASP ASN LYS PHE GLY VAL GLU GLN PRO SEQRES 14 A 1970 GLU GLY ASP GLU ASP LEU THR LYS GLU LYS GLY HIS GLY SEQRES 15 A 1970 GLY CYS GLY ARG TYR GLN PRO ARG ILE ARG ARG SER GLY SEQRES 16 A 1970 LEU GLU LEU TYR ALA GLU TRP LYS HIS VAL ASN GLU ASP SEQRES 17 A 1970 SER GLN GLU LYS LYS ILE LEU LEU SER PRO GLU ARG VAL SEQRES 18 A 1970 HIS GLU ILE PHE LYS ARG ILE SER ASP GLU GLU CYS PHE SEQRES 19 A 1970 VAL LEU GLY MET GLU PRO ARG TYR ALA ARG PRO GLU TRP SEQRES 20 A 1970 MET ILE VAL THR VAL LEU PRO VAL PRO PRO LEU SER VAL SEQRES 21 A 1970 ARG PRO ALA VAL VAL MET GLN GLY SER ALA ARG ASN GLN SEQRES 22 A 1970 ASP ASP LEU THR HIS LYS LEU ALA ASP ILE VAL LYS ILE SEQRES 23 A 1970 ASN ASN GLN LEU ARG ARG ASN GLU GLN ASN GLY ALA ALA SEQRES 24 A 1970 ALA HIS VAL ILE ALA GLU ASP VAL LYS LEU LEU GLN PHE SEQRES 25 A 1970 HIS VAL ALA THR MET VAL ASP ASN GLU LEU PRO GLY LEU SEQRES 26 A 1970 PRO ARG ALA MET GLN LYS SER GLY ARG PRO LEU LYS SER SEQRES 27 A 1970 LEU LYS GLN ARG LEU LYS GLY LYS GLU GLY ARG VAL ARG SEQRES 28 A 1970 GLY ASN LEU MET GLY LYS ARG VAL ASP PHE SER ALA ARG SEQRES 29 A 1970 THR VAL ILE THR PRO ASP PRO ASN LEU SER ILE ASP GLN SEQRES 30 A 1970 VAL GLY VAL PRO ARG SER ILE ALA ALA ASN MET THR PHE SEQRES 31 A 1970 ALA GLU ILE VAL THR PRO PHE ASN ILE ASP ARG LEU GLN SEQRES 32 A 1970 GLU LEU VAL ARG ARG GLY ASN SER GLN TYR PRO GLY ALA SEQRES 33 A 1970 LYS TYR ILE ILE ARG ASP ASN GLY ASP ARG ILE ASP LEU SEQRES 34 A 1970 ARG PHE HIS PRO LYS PRO SER ASP LEU HIS LEU GLN THR SEQRES 35 A 1970 GLY TYR LYS VAL GLU ARG HIS MET CYS ASP GLY ASP ILE SEQRES 36 A 1970 VAL ILE PHE ASN ARG GLN PRO THR LEU HIS LYS MET SER SEQRES 37 A 1970 MET MET GLY HIS ARG VAL ARG ILE LEU PRO TRP SER THR SEQRES 38 A 1970 PHE ARG LEU ASN LEU SER VAL THR THR PRO TYR ASN ALA SEQRES 39 A 1970 ASP PHE ASP GLY ASP GLU MET ASN LEU HIS LEU PRO GLN SEQRES 40 A 1970 SER LEU GLU THR ARG ALA GLU ILE GLN GLU LEU ALA MET SEQRES 41 A 1970 VAL PRO ARG MET ILE VAL THR PRO GLN SER ASN ARG PRO SEQRES 42 A 1970 VAL MET GLY ILE VAL GLN ASP THR LEU THR ALA VAL ARG SEQRES 43 A 1970 LYS PHE THR LYS ARG ASP VAL PHE LEU GLU ARG GLY GLU SEQRES 44 A 1970 VAL MET ASN LEU LEU MET PHE LEU SER THR TRP ASP GLY SEQRES 45 A 1970 LYS VAL PRO GLN PRO ALA ILE LEU LYS PRO ARG PRO LEU SEQRES 46 A 1970 TRP THR GLY LYS GLN ILE PHE SER LEU ILE ILE PRO GLY SEQRES 47 A 1970 HIS ILE ASN CYS ILE ARG THR HIS SER THR HIS PRO ASP SEQRES 48 A 1970 ASP GLU ASP SER GLY PRO TYR LYS HIS ILE SER PRO GLY SEQRES 49 A 1970 ASP THR LYS VAL VAL VAL GLU ASN GLY GLU LEU ILE MET SEQRES 50 A 1970 GLY ILE LEU CYS LYS LYS SER LEU GLY THR SER ALA GLY SEQRES 51 A 1970 SER LEU VAL HIS ILE SER TYR LEU GLU MET GLY HIS ASP SEQRES 52 A 1970 ILE THR ARG LEU PHE TYR SER ASN ILE GLN THR VAL ILE SEQRES 53 A 1970 ASN ASN TRP LEU LEU ILE GLU GLY HIS THR ILE GLY ILE SEQRES 54 A 1970 GLY ASP SER ILE ALA ASP SER LYS THR TYR GLN ASP ILE SEQRES 55 A 1970 GLN ASN THR ILE LYS LYS ALA LYS GLN ASP VAL ILE GLU SEQRES 56 A 1970 VAL ILE GLU LYS ALA HIS ASN ASN GLU LEU GLU PRO THR SEQRES 57 A 1970 PRO GLY ASN THR LEU ARG GLN THR PHE GLU ASN GLN VAL SEQRES 58 A 1970 ASN ARG ILE LEU ASN ASP ALA ARG ASP LYS THR GLY SER SEQRES 59 A 1970 SER ALA GLN LYS SER LEU SER GLU TYR ASN ASN PHE LYS SEQRES 60 A 1970 SER MET VAL VAL SER GLY ALA LYS GLY SER LYS ILE ASN SEQRES 61 A 1970 ILE SER GLN VAL ILE ALA VAL VAL GLY GLN GLN ASN VAL SEQRES 62 A 1970 GLU GLY LYS ARG ILE PRO PHE GLY PHE LYS HIS ARG THR SEQRES 63 A 1970 LEU PRO HIS PHE ILE LYS ASP ASP TYR GLY PRO GLU SER SEQRES 64 A 1970 ARG GLY PHE VAL GLU ASN SER TYR LEU ALA GLY LEU THR SEQRES 65 A 1970 PRO THR GLU PHE PHE PHE HIS ALA MET GLY GLY ARG GLU SEQRES 66 A 1970 GLY LEU ILE ASP THR ALA VAL LYS THR ALA GLU THR GLY SEQRES 67 A 1970 TYR ILE GLN ARG ARG LEU ILE LYS SER MET GLU SER VAL SEQRES 68 A 1970 MET VAL LYS TYR ASP ALA THR VAL ARG ASN SER ILE ASN SEQRES 69 A 1970 GLN VAL VAL GLN LEU ARG TYR GLY GLU ASP GLY LEU ALA SEQRES 70 A 1970 GLY GLU SER VAL GLU PHE GLN ASN LEU ALA THR LEU LYS SEQRES 71 A 1970 PRO SER ASN LYS ALA PHE GLU LYS LYS PHE ARG PHE ASP SEQRES 72 A 1970 TYR THR ASN GLU ARG ALA LEU ARG ARG THR LEU GLN GLU SEQRES 73 A 1970 ASP LEU VAL LYS ASP VAL LEU SER ASN ALA HIS ILE GLN SEQRES 74 A 1970 ASN GLU LEU GLU ARG GLU PHE GLU ARG MET ARG GLU ASP SEQRES 75 A 1970 ARG GLU VAL LEU ARG VAL ILE PHE PRO THR GLY ASP SER SEQRES 76 A 1970 LYS VAL VAL LEU PRO CYS ASN LEU LEU ARG MET ILE TRP SEQRES 77 A 1970 ASN ALA GLN LYS ILE PHE HIS ILE ASN PRO ARG LEU PRO SEQRES 78 A 1970 SER ASP LEU HIS PRO ILE LYS VAL VAL GLU GLY VAL LYS SEQRES 79 A 1970 GLU LEU SER LYS LYS LEU VAL ILE VAL ASN GLY ASP ASP SEQRES 80 A 1970 PRO LEU SER ARG GLN ALA GLN GLU ASN ALA THR LEU LEU SEQRES 81 A 1970 PHE ASN ILE HIS LEU ARG SER THR LEU CYS SER ARG ARG SEQRES 82 A 1970 MET ALA GLU GLU PHE ARG LEU SER GLY GLU ALA PHE ASP SEQRES 83 A 1970 TRP LEU LEU GLY GLU ILE GLU SER LYS PHE ASN GLN ALA SEQRES 84 A 1970 ILE ALA HIS PRO GLY GLU MET VAL GLY ALA LEU ALA ALA SEQRES 85 A 1970 GLN SER LEU GLY GLU PRO ALA THR GLN MET THR LEU ASN SEQRES 86 A 1970 THR PHE HIS TYR ALA GLY VAL SER ALA LYS ASN VAL THR SEQRES 87 A 1970 LEU GLY VAL PRO ARG LEU LYS GLU LEU ILE ASN ILE SER SEQRES 88 A 1970 LYS LYS PRO LYS THR PRO SER LEU THR VAL PHE LEU LEU SEQRES 89 A 1970 GLY GLN SER ALA ARG ASP ALA GLU ARG ALA LYS ASP ILE SEQRES 90 A 1970 LEU CYS ARG LEU GLU HIS THR THR LEU ARG LYS VAL THR SEQRES 91 A 1970 ALA ASN THR ALA ILE TYR TYR ASP PRO ASN PRO GLN SER SEQRES 92 A 1970 THR VAL VAL ALA GLU ASP GLN GLU TRP VAL ASN VAL TYR SEQRES 93 A 1970 TYR GLU MET PRO ASP PHE ASP VAL ALA ARG ILE SER PRO SEQRES 94 A 1970 TRP LEU LEU ARG VAL GLU LEU ASP ARG LYS HIS MET THR SEQRES 95 A 1970 ASP ARG LYS LEU THR MET GLU GLN ILE ALA GLU LYS ILE SEQRES 96 A 1970 ASN ALA GLY PHE GLY ASP ASP LEU ASN CYS ILE PHE ASN SEQRES 97 A 1970 ASP ASP ASN ALA GLU LYS LEU VAL LEU ARG ILE ARG ILE SEQRES 98 A 1970 MET ASN SER ASP GLU ASN LYS MET GLN GLU GLU GLU GLU SEQRES 99 A 1970 VAL VAL ASP LYS MET ASP ASP ASP VAL PHE LEU ARG CYS SEQRES 100 A 1970 ILE GLU SER ASN MET LEU THR ASP MET THR LEU GLN GLY SEQRES 101 A 1970 ILE GLU GLN ILE SER LYS VAL TYR MET HIS LEU PRO GLN SEQRES 102 A 1970 THR ASP ASN LYS LYS LYS ILE ILE ILE THR GLU ASP GLY SEQRES 103 A 1970 GLU PHE LYS ALA LEU GLN GLU TRP ILE LEU GLU THR ASP SEQRES 104 A 1970 GLY VAL SER LEU MET ARG VAL LEU SER GLU LYS ASP VAL SEQRES 105 A 1970 ASP PRO VAL ARG THR THR SER ASN ASP ILE VAL GLU ILE SEQRES 106 A 1970 PHE THR VAL LEU GLY ILE GLU ALA VAL ARG LYS ALA LEU SEQRES 107 A 1970 GLU ARG GLU LEU TYR HIS VAL ILE SER PHE ASP GLY SER SEQRES 108 A 1970 TYR VAL ASN TYR ARG HIS LEU ALA LEU LEU CYS ASP THR SEQRES 109 A 1970 MET THR CYS ARG GLY HIS LEU MET ALA ILE THR ARG HIS SEQRES 110 A 1970 GLY VAL ASN ARG GLN ASP THR GLY PRO LEU MET LYS CYS SEQRES 111 A 1970 SER PHE GLU GLU THR VAL ASP VAL LEU MET GLU ALA ALA SEQRES 112 A 1970 ALA HIS GLY GLU SER ASP PRO MET LYS GLY VAL SER GLU SEQRES 113 A 1970 ASN ILE MET LEU GLY GLN LEU ALA PRO ALA GLY THR GLY SEQRES 114 A 1970 CYS PHE ASP LEU LEU LEU ASP ALA GLU LYS CYS LYS TYR SEQRES 115 A 1970 GLY MET GLU ILE PRO THR ASN ILE PRO GLY LEU GLY ALA SEQRES 116 A 1970 ALA GLY PRO THR GLY MET PHE PHE GLY SER ALA PRO SER SEQRES 117 A 1970 PRO MET GLY GLY ILE SER PRO ALA MET THR PRO TRP ASN SEQRES 118 A 1970 GLN GLY ALA THR PRO ALA TYR GLY ALA TRP SER PRO SER SEQRES 119 A 1970 VAL GLY SER GLY MET THR PRO GLY ALA ALA GLY PHE SER SEQRES 120 A 1970 PRO SER ALA ALA SER ASP ALA SER GLY PHE SER PRO GLY SEQRES 121 A 1970 TYR SER PRO ALA TRP SER PRO THR PRO GLY SER PRO GLY SEQRES 122 A 1970 SER PRO GLY PRO SER SER PRO TYR ILE PRO SER PRO GLY SEQRES 123 A 1970 GLY ALA MET SER PRO SER TYR SER PRO THR SER PRO ALA SEQRES 124 A 1970 TYR GLU PRO ARG SER PRO GLY GLY TYR THR PRO GLN SER SEQRES 125 A 1970 PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO THR SEQRES 126 A 1970 SER PRO SER TYR SER PRO THR SER PRO ASN TYR SER PRO SEQRES 127 A 1970 THR SER PRO SER TYR SER PRO THR SER PRO SER TYR SER SEQRES 128 A 1970 PRO THR SER PRO SER TYR SER PRO THR SER PRO SER TYR SEQRES 129 A 1970 SER PRO THR SER PRO SER TYR SER PRO THR SER PRO SER SEQRES 130 A 1970 TYR SER PRO THR SER PRO SER TYR SER PRO THR SER PRO SEQRES 131 A 1970 SER TYR SER PRO THR SER PRO SER TYR SER PRO THR SER SEQRES 132 A 1970 PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO THR SEQRES 133 A 1970 SER PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO SEQRES 134 A 1970 THR SER PRO SER TYR SER PRO THR SER PRO SER TYR SER SEQRES 135 A 1970 PRO THR SER PRO ASN TYR SER PRO THR SER PRO ASN TYR SEQRES 136 A 1970 THR PRO THR SER PRO SER TYR SER PRO THR SER PRO SER SEQRES 137 A 1970 TYR SER PRO THR SER PRO ASN TYR THR PRO THR SER PRO SEQRES 138 A 1970 ASN TYR SER PRO THR SER PRO SER TYR SER PRO THR SER SEQRES 139 A 1970 PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO SER SEQRES 140 A 1970 SER PRO ARG TYR THR PRO GLN SER PRO THR TYR THR PRO SEQRES 141 A 1970 SER SER PRO SER TYR SER PRO SER SER PRO SER TYR SER SEQRES 142 A 1970 PRO THR SER PRO LYS TYR THR PRO THR SER PRO SER TYR SEQRES 143 A 1970 SER PRO SER SER PRO GLU TYR THR PRO THR SER PRO LYS SEQRES 144 A 1970 TYR SER PRO THR SER PRO LYS TYR SER PRO THR SER PRO SEQRES 145 A 1970 LYS TYR SER PRO THR SER PRO THR TYR SER PRO THR THR SEQRES 146 A 1970 PRO LYS TYR SER PRO THR SER PRO THR TYR SER PRO THR SEQRES 147 A 1970 SER PRO VAL TYR THR PRO THR SER PRO LYS TYR SER PRO SEQRES 148 A 1970 THR SER PRO THR TYR SER PRO THR SER PRO LYS TYR SER SEQRES 149 A 1970 PRO THR SER PRO THR TYR SER PRO THR SER PRO LYS GLY SEQRES 150 A 1970 SER THR TYR SER PRO THR SER PRO GLY TYR SER PRO THR SEQRES 151 A 1970 SER PRO THR TYR SER LEU THR SER PRO ALA ILE SER PRO SEQRES 152 A 1970 ASP ASP SER ASP GLU GLU ASN SEQRES 1 B 1174 MET TYR ASP ALA ASP GLU ASP MET GLN TYR ASP GLU ASP SEQRES 2 B 1174 ASP ASP GLU ILE THR PRO ASP LEU TRP GLN GLU ALA CYS SEQRES 3 B 1174 TRP ILE VAL ILE SER SER TYR PHE ASP GLU LYS GLY LEU SEQRES 4 B 1174 VAL ARG GLN GLN LEU ASP SER PHE ASP GLU PHE ILE GLN SEQRES 5 B 1174 MET SER VAL GLN ARG ILE VAL GLU ASP ALA PRO PRO ILE SEQRES 6 B 1174 ASP LEU GLN ALA GLU ALA GLN HIS ALA SER GLY GLU VAL SEQRES 7 B 1174 GLU GLU PRO PRO ARG TYR LEU LEU LYS PHE GLU GLN ILE SEQRES 8 B 1174 TYR LEU SER LYS PRO THR HIS TRP GLU ARG ASP GLY ALA SEQRES 9 B 1174 PRO SER PRO MET MET PRO ASN GLU ALA ARG LEU ARG ASN SEQRES 10 B 1174 LEU THR TYR SER ALA PRO LEU TYR VAL ASP ILE THR LYS SEQRES 11 B 1174 THR VAL ILE LYS GLU GLY GLU GLU GLN LEU GLN THR GLN SEQRES 12 B 1174 HIS GLN LYS THR PHE ILE GLY LYS ILE PRO ILE MET LEU SEQRES 13 B 1174 ARG SER THR TYR CYS LEU LEU ASN GLY LEU THR ASP ARG SEQRES 14 B 1174 ASP LEU CYS GLU LEU ASN GLU CYS PRO LEU ASP PRO GLY SEQRES 15 B 1174 GLY TYR PHE ILE ILE ASN GLY SER GLU LYS VAL LEU ILE SEQRES 16 B 1174 ALA GLN GLU LYS MET ALA THR ASN THR VAL TYR VAL PHE SEQRES 17 B 1174 ALA LYS LYS ASP SER LYS TYR ALA TYR THR GLY GLU CYS SEQRES 18 B 1174 ARG SER CYS LEU GLU ASN SER SER ARG PRO THR SER THR SEQRES 19 B 1174 ILE TRP VAL SER MET LEU ALA ARG GLY GLY GLN GLY ALA SEQRES 20 B 1174 LYS LYS SER ALA ILE GLY GLN ARG ILE VAL ALA THR LEU SEQRES 21 B 1174 PRO TYR ILE LYS GLN GLU VAL PRO ILE ILE ILE VAL PHE SEQRES 22 B 1174 ARG ALA LEU GLY PHE VAL SER ASP ARG ASP ILE LEU GLU SEQRES 23 B 1174 HIS ILE ILE TYR ASP PHE GLU ASP PRO GLU MET MET GLU SEQRES 24 B 1174 MET VAL LYS PRO SER LEU ASP GLU ALA PHE VAL ILE GLN SEQRES 25 B 1174 GLU GLN ASN VAL ALA LEU ASN PHE ILE GLY SER ARG GLY SEQRES 26 B 1174 ALA LYS PRO GLY VAL THR LYS GLU LYS ARG ILE LYS TYR SEQRES 27 B 1174 ALA LYS GLU VAL LEU GLN LYS GLU MET LEU PRO HIS VAL SEQRES 28 B 1174 GLY VAL SER ASP PHE CYS GLU THR LYS LYS ALA TYR PHE SEQRES 29 B 1174 LEU GLY TYR MET VAL HIS ARG LEU LEU LEU ALA ALA LEU SEQRES 30 B 1174 GLY ARG ARG GLU LEU ASP ASP ARG ASP HIS TYR GLY ASN SEQRES 31 B 1174 LYS ARG LEU ASP LEU ALA GLY PRO LEU LEU ALA PHE LEU SEQRES 32 B 1174 PHE ARG GLY MET PHE LYS ASN LEU LEU LYS GLU VAL ARG SEQRES 33 B 1174 ILE TYR ALA GLN LYS PHE ILE ASP ARG GLY LYS ASP PHE SEQRES 34 B 1174 ASN LEU GLU LEU ALA ILE LYS THR ARG ILE ILE SER ASP SEQRES 35 B 1174 GLY LEU LYS TYR SER LEU ALA THR GLY ASN TRP GLY ASP SEQRES 36 B 1174 GLN LYS LYS ALA HIS GLN ALA ARG ALA GLY VAL SER GLN SEQRES 37 B 1174 VAL LEU ASN ARG LEU THR PHE ALA SER THR LEU SER HIS SEQRES 38 B 1174 LEU ARG ARG LEU ASN SER PRO ILE GLY ARG ASP GLY LYS SEQRES 39 B 1174 LEU ALA LYS PRO ARG GLN LEU HIS ASN THR LEU TRP GLY SEQRES 40 B 1174 MET VAL CYS PRO ALA GLU THR PRO GLU GLY HIS ALA VAL SEQRES 41 B 1174 GLY LEU VAL LYS ASN LEU ALA LEU MET ALA TYR ILE SER SEQRES 42 B 1174 VAL GLY SER GLN PRO SER PRO ILE LEU GLU PHE LEU GLU SEQRES 43 B 1174 GLU TRP SER MET GLU ASN LEU GLU GLU ILE SER PRO ALA SEQRES 44 B 1174 ALA ILE ALA ASP ALA THR LYS ILE PHE VAL ASN GLY CYS SEQRES 45 B 1174 TRP VAL GLY ILE HIS LYS ASP PRO GLU GLN LEU MET ASN SEQRES 46 B 1174 THR LEU ARG LYS LEU ARG ARG GLN MET ASP ILE ILE VAL SEQRES 47 B 1174 SER GLU VAL SER MET ILE ARG ASP ILE ARG GLU ARG GLU SEQRES 48 B 1174 ILE ARG ILE TYR THR ASP ALA GLY ARG ILE CYS ARG PRO SEQRES 49 B 1174 LEU LEU ILE VAL GLU LYS GLN LYS LEU LEU LEU LYS LYS SEQRES 50 B 1174 ARG HIS ILE ASP GLN LEU LYS GLU ARG GLU TYR ASN ASN SEQRES 51 B 1174 TYR SER TRP GLN ASP LEU VAL ALA SER GLY VAL VAL GLU SEQRES 52 B 1174 TYR ILE ASP THR LEU GLU GLU GLU THR VAL MET LEU ALA SEQRES 53 B 1174 MET THR PRO ASP ASP LEU GLN GLU LYS GLU VAL ALA TYR SEQRES 54 B 1174 CYS SER THR TYR THR HIS CYS GLU ILE HIS PRO SER MET SEQRES 55 B 1174 ILE LEU GLY VAL CYS ALA SER ILE ILE PRO PHE PRO ASP SEQRES 56 B 1174 HIS ASN GLN SER PRO ARG ASN THR TYR GLN SER ALA MET SEQRES 57 B 1174 GLY LYS GLN ALA MET GLY VAL TYR ILE THR ASN PHE HIS SEQRES 58 B 1174 VAL ARG MET ASP THR LEU ALA HIS VAL LEU TYR TYR PRO SEQRES 59 B 1174 GLN LYS PRO LEU VAL THR THR ARG SER MET GLU TYR LEU SEQRES 60 B 1174 ARG PHE ARG GLU LEU PRO ALA GLY ILE ASN SER ILE VAL SEQRES 61 B 1174 ALA ILE ALA SER TYR THR GLY TYR ASN GLN GLU ASP SER SEQRES 62 B 1174 VAL ILE MET ASN ARG SER ALA VAL ASP ARG GLY PHE PHE SEQRES 63 B 1174 ARG SER VAL PHE TYR ARG SER TYR LYS GLU GLN GLU SER SEQRES 64 B 1174 LYS LYS GLY PHE ASP GLN GLU GLU VAL PHE GLU LYS PRO SEQRES 65 B 1174 THR ARG GLU THR CYS GLN GLY MET ARG HIS ALA ILE TYR SEQRES 66 B 1174 ASP LYS LEU ASP ASP ASP GLY LEU ILE ALA PRO GLY VAL SEQRES 67 B 1174 ARG VAL SER GLY ASP ASP VAL ILE ILE GLY LYS THR VAL SEQRES 68 B 1174 THR LEU PRO GLU ASN GLU ASP GLU LEU GLU GLY THR ASN SEQRES 69 B 1174 ARG ARG TYR THR LYS ARG ASP CYS SER THR PHE LEU ARG SEQRES 70 B 1174 THR SER GLU THR GLY ILE VAL ASP GLN VAL MET VAL THR SEQRES 71 B 1174 LEU ASN GLN GLU GLY TYR LYS PHE CYS LYS ILE ARG VAL SEQRES 72 B 1174 ARG SER VAL ARG ILE PRO GLN ILE GLY ASP LYS PHE ALA SEQRES 73 B 1174 SER ARG HIS GLY GLN LYS GLY THR CYS GLY ILE GLN TYR SEQRES 74 B 1174 ARG GLN GLU ASP MET PRO PHE THR CYS GLU GLY ILE THR SEQRES 75 B 1174 PRO ASP ILE ILE ILE ASN PRO HIS ALA ILE PRO SER ARG SEQRES 76 B 1174 MET THR ILE GLY HIS LEU ILE GLU CYS LEU GLN GLY LYS SEQRES 77 B 1174 VAL SER ALA ASN LYS GLY GLU ILE GLY ASP ALA THR PRO SEQRES 78 B 1174 PHE ASN ASP ALA VAL ASN VAL GLN LYS ILE SER ASN LEU SEQRES 79 B 1174 LEU SER ASP TYR GLY TYR HIS LEU ARG GLY ASN GLU VAL SEQRES 80 B 1174 LEU TYR ASN GLY PHE THR GLY ARG LYS ILE THR SER GLN SEQRES 81 B 1174 ILE PHE ILE GLY PRO THR TYR TYR GLN ARG LEU LYS HIS SEQRES 82 B 1174 MET VAL ASP ASP LYS ILE HIS SER ARG ALA ARG GLY PRO SEQRES 83 B 1174 ILE GLN ILE LEU ASN ARG GLN PRO MET GLU GLY ARG SER SEQRES 84 B 1174 ARG ASP GLY GLY LEU ARG PHE GLY GLU MET GLU ARG ASP SEQRES 85 B 1174 CYS GLN ILE ALA HIS GLY ALA ALA GLN PHE LEU ARG GLU SEQRES 86 B 1174 ARG LEU PHE GLU ALA SER ASP PRO TYR GLN VAL HIS VAL SEQRES 87 B 1174 CYS ASN LEU CYS GLY ILE MET ALA ILE ALA ASN THR ARG SEQRES 88 B 1174 THR HIS THR TYR GLU CYS ARG GLY CYS ARG ASN LYS THR SEQRES 89 B 1174 GLN ILE SER LEU VAL ARG MET PRO TYR ALA CYS LYS LEU SEQRES 90 B 1174 LEU PHE GLN GLU LEU MET SER MET SER ILE ALA PRO ARG SEQRES 91 B 1174 MET MET SER VAL SEQRES 1 C 275 MET PRO TYR ALA ASN GLN PRO THR VAL ARG ILE THR GLU SEQRES 2 C 275 LEU THR ASP GLU ASN VAL LYS PHE ILE ILE GLU ASN THR SEQRES 3 C 275 ASP LEU ALA VAL ALA ASN SER ILE ARG ARG VAL PHE ILE SEQRES 4 C 275 ALA GLU VAL PRO ILE ILE ALA ILE ASP TRP VAL GLN ILE SEQRES 5 C 275 ASP ALA ASN SER SER VAL LEU HIS ASP GLU PHE ILE ALA SEQRES 6 C 275 HIS ARG LEU GLY LEU ILE PRO LEU THR SER ASP ASP ILE SEQRES 7 C 275 VAL ASP LYS LEU GLN TYR SER ARG ASP CYS THR CYS GLU SEQRES 8 C 275 GLU PHE CYS PRO GLU CYS SER VAL GLU PHE THR LEU ASP SEQRES 9 C 275 VAL ARG CYS ASN GLU ASP GLN THR ARG HIS VAL THR SER SEQRES 10 C 275 ARG ASP LEU ILE SER ASN SER PRO ARG VAL ILE PRO VAL SEQRES 11 C 275 THR SER ARG ASN ARG ASP ASN ASP PRO SER ASP TYR VAL SEQRES 12 C 275 GLU GLN ASP ASP ILE LEU ILE VAL LYS LEU ARG LYS GLY SEQRES 13 C 275 GLN GLU LEU ARG LEU ARG ALA TYR ALA LYS LYS GLY PHE SEQRES 14 C 275 GLY LYS GLU HIS ALA LYS TRP ASN PRO THR ALA GLY VAL SEQRES 15 C 275 ALA PHE GLU TYR ASP PRO ASP ASN ALA LEU ARG HIS THR SEQRES 16 C 275 VAL TYR PRO LYS PRO GLU GLU TRP PRO LYS SER GLU TYR SEQRES 17 C 275 SER GLU LEU ASP GLU ASP GLU SER GLN ALA PRO TYR ASP SEQRES 18 C 275 PRO ASN GLY LYS PRO GLU ARG PHE TYR TYR ASN VAL GLU SEQRES 19 C 275 SER CYS GLY SER LEU ARG PRO GLU THR ILE VAL LEU SER SEQRES 20 C 275 ALA LEU SER GLY LEU LYS LYS LYS LEU SER ASP LEU GLN SEQRES 21 C 275 THR GLN LEU SER HIS GLU ILE GLN SER ASP VAL LEU THR SEQRES 22 C 275 ILE ASN SEQRES 1 D 142 MET ALA ALA GLY GLY SER ASP PRO ARG ALA GLY ASP VAL SEQRES 2 D 142 GLU GLU ASP ALA SER GLN LEU ILE PHE PRO LYS GLU PHE SEQRES 3 D 142 GLU THR ALA GLU THR LEU LEU ASN SER GLU VAL HIS MET SEQRES 4 D 142 LEU LEU GLU HIS ARG LYS GLN GLN ASN GLU SER ALA GLU SEQRES 5 D 142 ASP GLU GLN GLU LEU SER GLU VAL PHE MET LYS THR LEU SEQRES 6 D 142 ASN TYR THR ALA ARG PHE SER ARG PHE LYS ASN ARG GLU SEQRES 7 D 142 THR ILE ALA SER VAL ARG SER LEU LEU LEU GLN LYS LYS SEQRES 8 D 142 LEU HIS LYS PHE GLU LEU ALA CYS LEU ALA ASN LEU CYS SEQRES 9 D 142 PRO GLU THR ALA GLU GLU SER LYS ALA LEU ILE PRO SER SEQRES 10 D 142 LEU GLU GLY ARG PHE GLU ASP GLU GLU LEU GLN GLN ILE SEQRES 11 D 142 LEU ASP ASP ILE GLN THR LYS ARG SER PHE GLN TYR SEQRES 1 E 210 MET ASP ASP GLU GLU GLU THR TYR ARG LEU TRP LYS ILE SEQRES 2 E 210 ARG LYS THR ILE MET GLN LEU CYS HIS ASP ARG GLY TYR SEQRES 3 E 210 LEU VAL THR GLN ASP GLU LEU ASP GLN THR LEU GLU GLU SEQRES 4 E 210 PHE LYS ALA GLN PHE GLY ASP LYS PRO SER GLU GLY ARG SEQRES 5 E 210 PRO ARG ARG THR ASP LEU THR VAL LEU VAL ALA HIS ASN SEQRES 6 E 210 ASP ASP PRO THR ASP GLN MET PHE VAL PHE PHE PRO GLU SEQRES 7 E 210 GLU PRO LYS VAL GLY ILE LYS THR ILE LYS VAL TYR CYS SEQRES 8 E 210 GLN ARG MET GLN GLU GLU ASN ILE THR ARG ALA LEU ILE SEQRES 9 E 210 VAL VAL GLN GLN GLY MET THR PRO SER ALA LYS GLN SER SEQRES 10 E 210 LEU VAL ASP MET ALA PRO LYS TYR ILE LEU GLU GLN PHE SEQRES 11 E 210 LEU GLN GLN GLU LEU LEU ILE ASN ILE THR GLU HIS GLU SEQRES 12 E 210 LEU VAL PRO GLU HIS VAL VAL MET THR LYS GLU GLU VAL SEQRES 13 E 210 THR GLU LEU LEU ALA ARG TYR LYS LEU ARG GLU ASN GLN SEQRES 14 E 210 LEU PRO ARG ILE GLN ALA GLY ASP PRO VAL ALA ARG TYR SEQRES 15 E 210 PHE GLY ILE LYS ARG GLY GLN VAL VAL LYS ILE ILE ARG SEQRES 16 E 210 PRO SER GLU THR ALA GLY ARG TYR ILE THR TYR ARG LEU SEQRES 17 E 210 VAL GLN SEQRES 1 F 127 MET SER ASP ASN GLU ASP ASN PHE ASP GLY ASP ASP PHE SEQRES 2 F 127 ASP ASP VAL GLU GLU ASP GLU GLY LEU ASP ASP LEU GLU SEQRES 3 F 127 ASN ALA GLU GLU GLU GLY GLN GLU ASN VAL GLU ILE LEU SEQRES 4 F 127 PRO SER GLY GLU ARG PRO GLN ALA ASN GLN LYS ARG ILE SEQRES 5 F 127 THR THR PRO TYR MET THR LYS TYR GLU ARG ALA ARG VAL SEQRES 6 F 127 LEU GLY THR ARG ALA LEU GLN ILE ALA MET CYS ALA PRO SEQRES 7 F 127 VAL MET VAL GLU LEU GLU GLY GLU THR ASP PRO LEU LEU SEQRES 8 F 127 ILE ALA MET LYS GLU LEU LYS ALA ARG LYS ILE PRO ILE SEQRES 9 F 127 ILE ILE ARG ARG TYR LEU PRO ASP GLY SER TYR GLU ASP SEQRES 10 F 127 TRP GLY VAL ASP GLU LEU ILE ILE SER ASP SEQRES 1 G 172 MET PHE TYR HIS ILE SER LEU GLU HIS GLU ILE LEU LEU SEQRES 2 G 172 HIS PRO ARG TYR PHE GLY PRO ASN LEU LEU ASN THR VAL SEQRES 3 G 172 LYS GLN LYS LEU PHE THR GLU VAL GLU GLY THR CYS THR SEQRES 4 G 172 GLY LYS TYR GLY PHE VAL ILE ALA VAL THR THR ILE ASP SEQRES 5 G 172 ASN ILE GLY ALA GLY VAL ILE GLN PRO GLY ARG GLY PHE SEQRES 6 G 172 VAL LEU TYR PRO VAL LYS TYR LYS ALA ILE VAL PHE ARG SEQRES 7 G 172 PRO PHE LYS GLY GLU VAL VAL ASP ALA VAL VAL THR GLN SEQRES 8 G 172 VAL ASN LYS VAL GLY LEU PHE THR GLU ILE GLY PRO MET SEQRES 9 G 172 SER CYS PHE ILE SER ARG HIS SER ILE PRO SER GLU MET SEQRES 10 G 172 GLU PHE ASP PRO ASN SER ASN PRO PRO CYS TYR LYS THR SEQRES 11 G 172 MET ASP GLU ASP ILE VAL ILE GLN GLN ASP ASP GLU ILE SEQRES 12 G 172 ARG LEU LYS ILE VAL GLY THR ARG VAL ASP LYS ASN ASP SEQRES 13 G 172 ILE PHE ALA ILE GLY SER LEU MET ASP ASP TYR LEU GLY SEQRES 14 G 172 LEU VAL SER SEQRES 1 H 150 MET ALA GLY ILE LEU PHE GLU ASP ILE PHE ASP VAL LYS SEQRES 2 H 150 ASP ILE ASP PRO GLU GLY LYS LYS PHE ASP ARG VAL SER SEQRES 3 H 150 ARG LEU HIS CYS GLU SER GLU SER PHE LYS MET ASP LEU SEQRES 4 H 150 ILE LEU ASP VAL ASN ILE GLN ILE TYR PRO VAL ASP LEU SEQRES 5 H 150 GLY ASP LYS PHE ARG LEU VAL ILE ALA SER THR LEU TYR SEQRES 6 H 150 GLU ASP GLY THR LEU ASP ASP GLY GLU TYR ASN PRO THR SEQRES 7 H 150 ASP ASP ARG PRO SER ARG ALA ASP GLN PHE GLU TYR VAL SEQRES 8 H 150 MET TYR GLY LYS VAL TYR ARG ILE GLU GLY ASP GLU THR SEQRES 9 H 150 SER THR GLU ALA ALA THR ARG LEU SER ALA TYR VAL SER SEQRES 10 H 150 TYR GLY GLY LEU LEU MET ARG LEU GLN GLY ASP ALA ASN SEQRES 11 H 150 ASN LEU HIS GLY PHE GLU VAL ASP SER ARG VAL TYR LEU SEQRES 12 H 150 LEU MET LYS LYS LEU ALA PHE SEQRES 1 I 125 MET GLU PRO ASP GLY THR TYR GLU PRO GLY PHE VAL GLY SEQRES 2 I 125 ILE ARG PHE CYS GLN GLU CYS ASN ASN MET LEU TYR PRO SEQRES 3 I 125 LYS GLU ASP LYS GLU ASN ARG ILE LEU LEU TYR ALA CYS SEQRES 4 I 125 ARG ASN CYS ASP TYR GLN GLN GLU ALA ASP ASN SER CYS SEQRES 5 I 125 ILE TYR VAL ASN LYS ILE THR HIS GLU VAL ASP GLU LEU SEQRES 6 I 125 THR GLN ILE ILE ALA ASP VAL SER GLN ASP PRO THR LEU SEQRES 7 I 125 PRO ARG THR GLU ASP HIS PRO CYS GLN LYS CYS GLY HIS SEQRES 8 I 125 LYS GLU ALA VAL PHE PHE GLN SER HIS SER ALA ARG ALA SEQRES 9 I 125 GLU ASP ALA MET ARG LEU TYR TYR VAL CYS THR ALA PRO SEQRES 10 I 125 HIS CYS GLY HIS ARG TRP THR GLU SEQRES 1 J 67 MET ILE ILE PRO VAL ARG CYS PHE THR CYS GLY LYS ILE SEQRES 2 J 67 VAL GLY ASN LYS TRP GLU ALA TYR LEU GLY LEU LEU GLN SEQRES 3 J 67 ALA GLU TYR THR GLU GLY ASP ALA LEU ASP ALA LEU GLY SEQRES 4 J 67 LEU LYS ARG TYR CYS CYS ARG ARG MET LEU LEU ALA HIS SEQRES 5 J 67 VAL ASP LEU ILE GLU LYS LEU LEU ASN TYR ALA PRO LEU SEQRES 6 J 67 GLU LYS SEQRES 1 K 117 MET ASN ALA PRO PRO ALA PHE GLU SER PHE LEU LEU PHE SEQRES 2 K 117 GLU GLY GLU LYS LYS ILE THR ILE ASN LYS ASP THR LYS SEQRES 3 K 117 VAL PRO ASN ALA CYS LEU PHE THR ILE ASN LYS GLU ASP SEQRES 4 K 117 HIS THR LEU GLY ASN ILE ILE LYS SER GLN LEU LEU LYS SEQRES 5 K 117 ASP PRO GLN VAL LEU PHE ALA GLY TYR LYS VAL PRO HIS SEQRES 6 K 117 PRO LEU GLU HIS LYS ILE ILE ILE ARG VAL GLN THR THR SEQRES 7 K 117 PRO ASP TYR SER PRO GLN GLU ALA PHE THR ASN ALA ILE SEQRES 8 K 117 THR ASP LEU ILE SER GLU LEU SER LEU LEU GLU GLU ARG SEQRES 9 K 117 PHE ARG VAL ALA ILE LYS ASP LYS GLN GLU GLY ILE GLU SEQRES 1 L 58 MET ASP THR GLN LYS ASP VAL GLN PRO PRO LYS GLN GLN SEQRES 2 L 58 PRO MET ILE TYR ILE CYS GLY GLU CYS HIS THR GLU ASN SEQRES 3 L 58 GLU ILE LYS SER ARG ASP PRO ILE ARG CYS ARG GLU CYS SEQRES 4 L 58 GLY TYR ARG ILE MET TYR LYS LYS ARG THR LYS ARG LEU SEQRES 5 L 58 VAL VAL PHE ASP ALA ARG SEQRES 1 N 48 DC DC DA DT DT DG DA DG DA DG DC DG DG SEQRES 2 N 48 DC DC DC DT DT DG DT DG DT DT DC DA DG SEQRES 3 N 48 DG DA DG DC DC DA DG DC DA DG DG DG DA SEQRES 4 N 48 DG DC DT DG DG DG DA DG DC SEQRES 1 P 15 G A G A G G G A A C C C A SEQRES 2 P 15 C U SEQRES 1 T 48 DG DC DT DC DC DC DA DG DC DT DC DC DC SEQRES 2 T 48 DT DG DC DT DG DG DC DT DC DC DG DA DG SEQRES 3 T 48 DT DG DG DG DT DT DC DT DG DC DC DG DC SEQRES 4 T 48 DT DC DT DC DA DA DT DG DG SEQRES 1 O 991 MET SER SER HIS HIS THR THR PHE PRO PHE ASP PRO GLU SEQRES 2 O 991 ARG ARG VAL ARG SER THR LEU LYS LYS VAL PHE GLY PHE SEQRES 3 O 991 ASP SER PHE LYS THR PRO LEU GLN GLU SER ALA THR MET SEQRES 4 O 991 ALA VAL VAL LYS GLY ASN LYS ASP VAL PHE VAL CYS MET SEQRES 5 O 991 PRO THR GLY ALA GLY LYS SER LEU CYS TYR GLN LEU PRO SEQRES 6 O 991 ALA LEU LEU ALA LYS GLY ILE THR ILE VAL VAL SER PRO SEQRES 7 O 991 LEU ILE ALA LEU ILE GLN ASP GLN VAL ASP HIS LEU LEU SEQRES 8 O 991 THR LEU LYS VAL ARG VAL SER SER LEU ASN SER LYS LEU SEQRES 9 O 991 SER ALA GLN GLU ARG LYS GLU LEU LEU ALA ASP LEU GLU SEQRES 10 O 991 ARG GLU LYS PRO GLN THR LYS ILE LEU TYR ILE THR PRO SEQRES 11 O 991 GLU MET ALA ALA SER SER SER PHE GLN PRO THR LEU ASN SEQRES 12 O 991 SER LEU VAL SER ARG HIS LEU LEU SER TYR LEU VAL VAL SEQRES 13 O 991 ASP GLU ALA HIS CYS VAL SER GLN TRP GLY HIS ASP PHE SEQRES 14 O 991 ARG PRO ASP TYR LEU ARG LEU GLY ALA LEU ARG SER ARG SEQRES 15 O 991 LEU GLY HIS ALA PRO CYS VAL ALA LEU THR ALA THR ALA SEQRES 16 O 991 THR PRO GLN VAL GLN GLU ASP VAL PHE ALA ALA LEU HIS SEQRES 17 O 991 LEU LYS LYS PRO VAL ALA ILE PHE LYS THR PRO CYS PHE SEQRES 18 O 991 ARG ALA ASN LEU PHE TYR ASP VAL GLN PHE LYS GLU LEU SEQRES 19 O 991 ILE SER ASP PRO TYR GLY ASN LEU LYS ASP PHE CYS LEU SEQRES 20 O 991 LYS ALA LEU GLY GLN GLU ALA ASP LYS GLY LEU SER GLY SEQRES 21 O 991 CYS GLY ILE VAL TYR CYS ARG THR ARG GLU ALA CYS GLU SEQRES 22 O 991 GLN LEU ALA ILE GLU LEU SER CYS ARG GLY VAL ASN ALA SEQRES 23 O 991 LYS ALA TYR HIS ALA GLY LEU LYS ALA SER GLU ARG THR SEQRES 24 O 991 LEU VAL GLN ASN ASP TRP MET GLU GLU LYS VAL PRO VAL SEQRES 25 O 991 ILE VAL ALA THR ILE SER PHE GLY MET GLY VAL ASP LYS SEQRES 26 O 991 ALA ASN VAL ARG PHE VAL ALA HIS TRP ASN ILE ALA LYS SEQRES 27 O 991 SER MET ALA GLY TYR TYR GLN GLU SER GLY ARG ALA GLY SEQRES 28 O 991 ARG ASP GLY LYS PRO SER TRP CYS ARG LEU TYR TYR SER SEQRES 29 O 991 ARG ASN ASP ARG ASP GLN VAL SER PHE LEU ILE ARG LYS SEQRES 30 O 991 GLU VAL ALA LYS LEU GLN GLU LYS ARG GLY ASN LYS ALA SEQRES 31 O 991 SER ASP LYS ALA THR ILE MET ALA PHE ASP ALA LEU VAL SEQRES 32 O 991 THR PHE CYS GLU GLU LEU GLY CYS ARG HIS ALA ALA ILE SEQRES 33 O 991 ALA LYS TYR PHE GLY ASP ALA LEU PRO ALA CYS ALA LYS SEQRES 34 O 991 GLY CYS ASP HIS CYS GLN ASN PRO THR ALA VAL ARG ARG SEQRES 35 O 991 ARG LEU GLU ALA LEU GLU ARG SER SER SER TRP SER LYS SEQRES 36 O 991 THR CYS ILE GLY PRO SER GLN GLY ASN GLY PHE ASP PRO SEQRES 37 O 991 GLU LEU TYR GLU GLY GLY ARG LYS GLY TYR GLY ASP PHE SEQRES 38 O 991 SER ARG TYR ASP GLU GLY SER GLY GLY SER GLY ASP GLU SEQRES 39 O 991 GLY ARG ASP GLU ALA HIS LYS ARG GLU TRP ASN LEU PHE SEQRES 40 O 991 TYR GLN LYS GLN MET GLN LEU ARG LYS GLY LYS ASP PRO SEQRES 41 O 991 LYS ILE GLU GLU PHE VAL PRO PRO ASP GLU ASN CYS PRO SEQRES 42 O 991 LEU LYS GLU ALA SER SER ARG ARG ILE PRO ARG LEU THR SEQRES 43 O 991 VAL LYS ALA ARG GLU HIS CYS LEU ARG LEU LEU GLU GLU SEQRES 44 O 991 ALA LEU SER SER ASN ARG GLN SER THR ARG THR ALA ASP SEQRES 45 O 991 GLU ALA ASP LEU ARG ALA LYS ALA VAL GLU LEU GLU HIS SEQRES 46 O 991 GLU THR PHE ARG ASN ALA LYS VAL ALA ASN LEU TYR LYS SEQRES 47 O 991 ALA SER VAL LEU LYS LYS VAL ALA ASP ILE HIS ARG ALA SEQRES 48 O 991 SER LYS ASP GLY GLN PRO TYR ASP MET GLY GLY SER ALA SEQRES 49 O 991 LYS SER CYS SER ALA GLN ALA GLU PRO PRO GLU PRO ASN SEQRES 50 O 991 GLU TYR ASP ILE PRO PRO ALA SER HIS VAL TYR SER LEU SEQRES 51 O 991 LYS PRO LYS ARG VAL GLY ALA GLY PHE PRO LYS GLY SER SEQRES 52 O 991 CYS PRO PHE GLN THR ALA THR GLU LEU MET GLU THR THR SEQRES 53 O 991 ARG ILE ARG GLU GLN ALA PRO GLN PRO GLU ARG GLY GLY SEQRES 54 O 991 GLU HIS GLU PRO PRO SER ARG PRO CYS GLY LEU LEU ASP SEQRES 55 O 991 GLU ASP GLY SER GLU PRO LEU PRO GLY PRO ARG GLY GLU SEQRES 56 O 991 VAL PRO GLY GLY SER ALA HIS TYR GLY GLY PRO SER PRO SEQRES 57 O 991 GLU LYS LYS ALA LYS SER SER SER GLY GLY SER SER LEU SEQRES 58 O 991 ALA LYS GLY ARG ALA SER LYS LYS GLN GLN LEU LEU ALA SEQRES 59 O 991 THR ALA ALA HIS LYS ASP SER GLN SER ILE ALA ARG PHE SEQRES 60 O 991 PHE CYS ARG ARG VAL GLU SER PRO ALA LEU LEU ALA SER SEQRES 61 O 991 ALA PRO GLU ALA GLU GLY ALA CYS PRO SER CYS GLU GLY SEQRES 62 O 991 VAL GLN GLY PRO PRO MET ALA PRO GLU LYS TYR THR GLY SEQRES 63 O 991 GLU GLU ASP GLY ALA GLY GLY HIS SER PRO ALA PRO PRO SEQRES 64 O 991 GLN THR GLU GLU CYS LEU ARG GLU ARG PRO SER THR CYS SEQRES 65 O 991 PRO PRO ARG ASP GLN GLY THR PRO GLU VAL GLN PRO THR SEQRES 66 O 991 PRO ALA LYS ASP THR TRP LYS GLY LYS ARG PRO ARG SER SEQRES 67 O 991 GLN GLN GLU ASN PRO GLU SER GLN PRO GLN LYS ARG PRO SEQRES 68 O 991 ARG PRO SER ALA LYS PRO SER VAL VAL ALA GLU VAL LYS SEQRES 69 O 991 GLY SER VAL SER ALA SER GLU GLN GLY THR LEU ASN PRO SEQRES 70 O 991 THR ALA GLN ASP PRO PHE GLN LEU SER ALA PRO GLY VAL SEQRES 71 O 991 SER LEU LYS GLU ALA ALA ASN VAL VAL VAL LYS CYS LEU SEQRES 72 O 991 THR PRO PHE TYR LYS GLU GLY LYS PHE ALA SER LYS GLU SEQRES 73 O 991 LEU PHE LYS GLY PHE ALA ARG HIS LEU SER HIS LEU LEU SEQRES 74 O 991 THR GLN LYS THR SER PRO GLY ARG SER VAL LYS GLU GLU SEQRES 75 O 991 ALA GLN ASN LEU ILE ARG HIS PHE PHE HIS GLY ARG ALA SEQRES 76 O 991 ARG CYS GLU SER GLU ALA ASP TRP HIS GLY LEU CYS GLY SEQRES 77 O 991 PRO GLN ARG HET ZN A2001 1 HET ZN A2002 1 HET MG A2003 1 HET ZN B1201 1 HET ZN C 301 1 HET ZN I 201 1 HET ZN I 202 1 HET ZN J 101 1 HET ZN L 101 1 HETNAM ZN ZINC ION HETNAM MG MAGNESIUM ION FORMUL 17 ZN 8(ZN 2+) FORMUL 19 MG MG 2+ HELIX 1 AA1 SER A 27 SER A 35 1 9 HELIX 2 AA2 ASP A 59 GLY A 63 5 5 HELIX 3 AA3 PHE A 99 ARG A 108 1 10 HELIX 4 AA4 ASN A 123 SER A 133 1 11 HELIX 5 AA5 GLN A 136 LYS A 151 1 16 HELIX 6 AA6 SER A 217 ILE A 228 1 12 HELIX 7 AA7 SER A 229 LEU A 236 1 8 HELIX 8 AA8 ARG A 244 TRP A 247 5 4 HELIX 9 AA9 ASP A 274 ASN A 296 1 23 HELIX 10 AB1 ALA A 299 ASP A 319 1 21 HELIX 11 AB2 SER A 338 LYS A 344 1 7 HELIX 12 AB3 GLY A 348 LEU A 354 1 7 HELIX 13 AB4 ARG A 382 MET A 388 1 7 HELIX 14 AB5 ASN A 398 GLY A 409 1 12 HELIX 15 AB6 LYS A 434 HIS A 439 1 6 HELIX 16 AB7 HIS A 465 MET A 467 5 3 HELIX 17 AB8 VAL A 488 ASN A 493 1 6 HELIX 18 AB9 SER A 508 ALA A 519 1 12 HELIX 19 AC1 MET A 520 MET A 524 5 5 HELIX 20 AC2 GLN A 539 THR A 549 1 11 HELIX 21 AC3 GLU A 556 MET A 565 1 10 HELIX 22 AC4 GLY A 588 ILE A 596 1 9 HELIX 23 AC5 CYS A 641 GLY A 646 1 6 HELIX 24 AC6 SER A 651 MET A 660 1 10 HELIX 25 AC7 GLY A 661 GLY A 684 1 24 HELIX 26 AC8 GLY A 688 ILE A 693 5 6 HELIX 27 AC9 ASP A 695 ASN A 722 1 28 HELIX 28 AD1 THR A 732 LEU A 760 1 29 HELIX 29 AD2 ASN A 764 SER A 772 1 9 HELIX 30 AD3 SER A 777 ALA A 786 1 10 HELIX 31 AD4 THR A 832 GLU A 869 1 38 HELIX 32 AD5 ARG A 890 ASP A 894 5 5 HELIX 33 AD6 SER A 912 ARG A 921 1 10 HELIX 34 AD7 ASN A 926 LEU A 934 1 9 HELIX 35 AD8 GLN A 935 ASN A 945 1 11 HELIX 36 AD9 ASN A 945 PHE A 970 1 26 HELIX 37 AE1 ASN A 982 PHE A 994 1 13 HELIX 38 AE2 HIS A 1005 LEU A 1020 1 16 HELIX 39 AE3 ASP A 1027 THR A 1038 1 12 HELIX 40 AE4 THR A 1038 LEU A 1049 1 12 HELIX 41 AE5 CYS A 1050 GLU A 1057 1 8 HELIX 42 AE6 SER A 1061 ILE A 1080 1 20 HELIX 43 AE7 MET A 1086 MET A 1102 1 17 HELIX 44 AE8 GLY A 1120 ASN A 1129 1 10 HELIX 45 AE9 GLY A 1145 ASP A 1150 1 6 HELIX 46 AF1 ASP A 1150 GLU A 1162 1 13 HELIX 47 AF2 VAL A 1186 TYR A 1197 1 12 HELIX 48 AF3 ASP A 1217 LYS A 1225 1 9 HELIX 49 AF4 THR A 1227 GLY A 1240 1 14 HELIX 50 AF5 ASP A 1280 ASP A 1295 1 16 HELIX 51 AF6 SER A 1342 GLU A 1349 1 8 HELIX 52 AF7 ASP A 1361 LEU A 1369 1 9 HELIX 53 AF8 GLY A 1370 PHE A 1388 1 19 HELIX 54 AF9 ASN A 1394 CYS A 1407 1 14 HELIX 55 AG1 THR A 1415 ARG A 1421 1 7 HELIX 56 AG2 GLY A 1425 SER A 1431 1 7 HELIX 57 AG3 GLU A 1434 GLY A 1446 1 13 HELIX 58 AG4 GLY A 1453 LEU A 1460 1 8 HELIX 59 AG5 ALA A 1466 GLY A 1469 5 4 HELIX 60 AG6 THR B 18 GLY B 38 1 21 HELIX 61 AG7 VAL B 40 ALA B 62 1 23 HELIX 62 AG8 MET B 109 ASN B 117 1 9 HELIX 63 AG9 THR B 167 LEU B 174 1 8 HELIX 64 AH1 ILE B 269 LEU B 276 1 8 HELIX 65 AH2 SER B 280 ILE B 289 1 10 HELIX 66 AH3 ASP B 294 ALA B 308 1 15 HELIX 67 AH4 GLU B 313 GLY B 325 1 13 HELIX 68 AH5 THR B 331 GLU B 346 1 16 HELIX 69 AH6 CYS B 357 LEU B 377 1 21 HELIX 70 AH7 LEU B 395 ASP B 424 1 30 HELIX 71 AH8 ASN B 430 ILE B 435 1 6 HELIX 72 AH9 THR B 437 GLY B 451 1 15 HELIX 73 AI1 THR B 474 LEU B 482 1 9 HELIX 74 AI2 HIS B 502 TRP B 506 5 5 HELIX 75 AI3 PRO B 538 TRP B 548 1 11 HELIX 76 AI4 SER B 557 ILE B 561 5 5 HELIX 77 AI5 ASP B 579 MET B 594 1 16 HELIX 78 AI6 LYS B 636 GLU B 645 1 10 HELIX 79 AI7 GLU B 645 ASN B 650 1 6 HELIX 80 AI8 SER B 652 SER B 659 1 8 HELIX 81 AI9 THR B 667 GLU B 671 1 5 HELIX 82 AJ1 THR B 678 GLN B 683 5 6 HELIX 83 AJ2 HIS B 699 LEU B 704 5 6 HELIX 84 AJ3 PHE B 713 ASN B 717 5 5 HELIX 85 AJ4 GLN B 718 GLY B 729 1 12 HELIX 86 AJ5 THR B 761 GLU B 765 5 5 HELIX 87 AJ6 ARG B 798 ARG B 803 1 6 HELIX 88 AJ7 ALA B 971 MET B 976 1 6 HELIX 89 AJ8 THR B 977 GLY B 994 1 18 HELIX 90 AJ9 ASN B 1007 ASP B 1017 1 11 HELIX 91 AK1 MET B 1054 LYS B 1058 5 5 HELIX 92 AK2 GLY B 1087 GLY B 1098 1 12 HELIX 93 AK3 ALA B 1099 PHE B 1108 1 10 HELIX 94 AK4 PRO B 1152 MET B 1165 1 14 HELIX 95 AK5 ASP C 27 GLU C 41 1 15 HELIX 96 AK6 HIS C 60 LEU C 70 1 11 HELIX 97 AK7 ASP C 77 LEU C 82 1 6 HELIX 98 AK8 ARG C 118 LEU C 120 5 3 HELIX 99 AK9 PRO C 129 ARG C 133 5 5 HELIX 100 AL1 HIS C 173 ASN C 177 5 5 HELIX 101 AL2 LYS C 199 TRP C 203 5 5 HELIX 102 AL3 ARG C 240 ASP C 270 1 31 HELIX 103 AL4 PRO D 23 THR D 28 1 6 HELIX 104 AL5 LEU D 33 SER D 50 1 18 HELIX 105 AL6 SER D 58 PHE D 71 1 14 HELIX 106 AL7 ASN D 76 GLN D 89 1 14 HELIX 107 AL8 HIS D 93 CYS D 104 1 12 HELIX 108 AL9 THR D 107 ILE D 115 1 9 HELIX 109 AM1 GLU D 123 ARG D 138 1 16 HELIX 110 AM2 ASP E 3 ARG E 24 1 22 HELIX 111 AM3 THR E 29 ASP E 34 1 6 HELIX 112 AM4 THR E 36 PHE E 44 1 9 HELIX 113 AM5 ARG E 54 THR E 59 5 6 HELIX 114 AM6 GLY E 83 ASN E 98 1 16 HELIX 115 AM7 THR E 111 MET E 121 1 11 HELIX 116 AM8 GLN E 132 LEU E 136 1 5 HELIX 117 AM9 ASN E 138 HIS E 142 5 5 HELIX 118 AN1 THR E 152 LYS E 164 1 13 HELIX 119 AN2 ARG E 166 LEU E 170 5 5 HELIX 120 AN3 ASP E 177 GLY E 184 1 8 HELIX 121 AN4 THR F 58 MET F 75 1 18 HELIX 122 AN5 ASP F 88 ARG F 100 1 13 HELIX 123 AN6 ASP F 121 LEU F 123 5 3 HELIX 124 AN7 HIS G 14 PHE G 18 5 5 HELIX 125 AN8 LEU G 22 GLU G 35 1 14 HELIX 126 AN9 SER H 83 PHE H 88 5 6 HELIX 127 AO1 ASN H 130 LEU H 132 5 3 HELIX 128 AO2 ASP I 63 ILE I 68 5 6 HELIX 129 AO3 ILE I 69 ASP I 75 5 7 HELIX 130 AO4 LYS J 17 ALA J 27 1 11 HELIX 131 AO5 THR J 30 GLY J 39 1 10 HELIX 132 AO6 ARG J 42 ALA J 51 1 10 HELIX 133 AO7 LEU J 55 LEU J 60 1 6 HELIX 134 AO8 PRO K 5 PHE K 10 5 6 HELIX 135 AO9 ASP K 39 LYS K 52 1 14 HELIX 136 AP1 SER K 82 GLY K 115 1 34 HELIX 137 AP2 ASP O 497 LYS O 516 1 20 HELIX 138 AP3 THR O 546 ARG O 569 1 24 HELIX 139 AP4 GLU O 573 ALA O 591 1 19 HELIX 140 AP5 VAL O 593 GLY O 615 1 23 SHEET 1 AA1 3 LEU A 15 ARG A 16 0 SHEET 2 AA1 3 ILE B1146 ARG B1150 1 O LEU B1148 N ARG A 16 SHEET 3 AA1 3 GLN B1115 CYS B1119 -1 N VAL B1116 O VAL B1149 SHEET 1 AA2 3 SER A1448 ASP A1449 0 SHEET 2 AA2 3 ARG A 20 GLN A 22 -1 N VAL A 21 O ASP A1449 SHEET 3 AA2 3 ARG B1170 MET B1172 -1 O ARG B1170 N GLN A 22 SHEET 1 AA3 2 GLY A 86 PHE A 95 0 SHEET 2 AA3 2 ILE A 249 VAL A 255 -1 O VAL A 250 N VAL A 94 SHEET 1 AA4 3 ARG A 190 SER A 194 0 SHEET 2 AA4 3 GLU A 197 GLU A 201 -1 O TYR A 199 N ARG A 192 SHEET 3 AA4 3 LYS A 213 LEU A 215 -1 O ILE A 214 N ALA A 200 SHEET 1 AA5 2 VAL A 264 VAL A 265 0 SHEET 2 AA5 2 ARG A 271 ASN A 272 -1 O ASN A 272 N VAL A 264 SHEET 1 AA6 2 LYS A 357 VAL A 359 0 SHEET 2 AA6 2 LEU B1084 PHE B1086 -1 O PHE B1086 N LYS A 357 SHEET 1 AA7 8 HIS B1060 ARG B1062 0 SHEET 2 AA7 8 SER A 362 PRO A 369 -1 N ARG A 364 O HIS B1060 SHEET 3 AA7 8 GLU A 500 HIS A 504 -1 O MET A 501 N THR A 365 SHEET 4 AA7 8 ILE A 455 ASN A 459 -1 N ILE A 457 O HIS A 504 SHEET 5 AA7 8 MET A 469 LEU A 477 -1 O MET A 470 N PHE A 458 SHEET 6 AA7 8 GLN A 377 PRO A 381 1 N VAL A 380 O ARG A 475 SHEET 7 AA7 8 PHE A 482 LEU A 484 -1 O ARG A 483 N GLY A 379 SHEET 8 AA7 8 SER A 362 PRO A 369 1 N VAL A 366 O PHE A 482 SHEET 1 AA8 4 THR A 389 ILE A 393 0 SHEET 2 AA8 4 LYS A 445 HIS A 449 -1 O VAL A 446 N GLU A 392 SHEET 3 AA8 4 ALA A 416 ILE A 420 -1 N LYS A 417 O GLU A 447 SHEET 4 AA8 4 ARG A 426 ASP A 428 -1 O ILE A 427 N ILE A 419 SHEET 1 AA9 2 VAL A 526 THR A 527 0 SHEET 2 AA9 2 ARG A 532 PRO A 533 -1 O ARG A 532 N THR A 527 SHEET 1 AB1 2 PHE A 554 LEU A 555 0 SHEET 2 AB1 2 TRP A 586 THR A 587 -1 O TRP A 586 N LEU A 555 SHEET 1 AB210 ILE A 579 LYS A 581 0 SHEET 2 AB210 TYR H 90 GLY H 101 -1 O VAL H 91 N LYS A 581 SHEET 3 AB210 ARG H 140 LEU H 148 -1 O MET H 145 N TYR H 90 SHEET 4 AB210 LYS H 55 ALA H 61 -1 N VAL H 59 O LEU H 144 SHEET 5 AB210 ILE H 4 ILE H 15 -1 N PHE H 10 O PHE H 56 SHEET 6 AB210 VAL H 25 SER H 32 -1 O HIS H 29 N ASP H 14 SHEET 7 AB210 ASP H 38 ASN H 44 -1 O LEU H 41 N LEU H 28 SHEET 8 AB210 LEU H 121 ASP H 128 -1 O GLN H 126 N ASP H 38 SHEET 9 AB210 ARG H 111 TYR H 118 -1 N LEU H 112 O GLY H 127 SHEET 10 AB210 TYR H 90 GLY H 101 -1 N ARG H 98 O TYR H 115 SHEET 1 AB3 3 CYS A 602 ILE A 603 0 SHEET 2 AB3 3 VAL A 629 GLU A 631 -1 O VAL A 630 N CYS A 602 SHEET 3 AB3 3 GLU A 634 MET A 637 -1 O MET A 637 N VAL A 629 SHEET 1 AB4 2 GLY A 789 GLN A 790 0 SHEET 2 AB4 2 PHE A 822 VAL A 823 -1 O VAL A 823 N GLY A 789 SHEET 1 AB5 3 MET A 872 VAL A 873 0 SHEET 2 AB5 3 VAL A 879 ARG A 880 -1 O ARG A 880 N MET A 872 SHEET 3 AB5 3 VAL A 886 GLN A 888 -1 O GLN A 888 N VAL A 879 SHEET 1 AB6 2 GLU A 902 ASN A 905 0 SHEET 2 AB6 2 LYS A 976 LEU A 979 -1 O LEU A 979 N GLU A 902 SHEET 1 AB7 4 VAL A1307 HIS A1310 0 SHEET 2 AB7 4 ILE A1335 THR A1338 -1 O GLU A1337 N TYR A1308 SHEET 3 AB7 4 LEU A1139 PHE A1142 -1 N VAL A1141 O LEU A1336 SHEET 4 AB7 4 THR A1358 SER A1359 -1 O THR A1358 N THR A1140 SHEET 1 AB8 2 THR A1164 THR A1165 0 SHEET 2 AB8 2 THR A1297 GLN A1299 -1 O LEU A1298 N THR A1164 SHEET 1 AB9 5 LEU A1243 PHE A1247 0 SHEET 2 AB9 5 VAL A1256 ILE A1261 -1 O ARG A1258 N ILE A1246 SHEET 3 AB9 5 TRP A1210 LEU A1216 -1 N VAL A1214 O LEU A1257 SHEET 4 AB9 5 THR A1170 TYR A1177 -1 N ALA A1171 O GLU A1215 SHEET 5 AB9 5 CYS I 52 LYS I 57 -1 O ASN I 56 N THR A1173 SHEET 1 AC1 2 LYS A1319 ILE A1322 0 SHEET 2 AC1 2 PHE A1328 LEU A1331 -1 O LEU A1331 N LYS A1319 SHEET 1 AC2 7 GLU D 30 THR D 31 0 SHEET 2 AC2 7 PHE G 2 LEU G 13 -1 O HIS G 4 N GLU D 30 SHEET 3 AC2 7 VAL G 66 PHE G 77 -1 O TYR G 72 N LEU G 7 SHEET 4 AC2 7 GLY G 57 ILE G 59 -1 N VAL G 58 O LEU G 67 SHEET 5 AC2 7 PHE A1471 LEU A1475 -1 N LEU A1475 O GLY G 57 SHEET 6 AC2 7 ILE F 104 TYR F 109 -1 O ILE F 105 N LEU A1474 SHEET 7 AC2 7 TYR F 115 GLY F 119 -1 O TRP F 118 N ILE F 106 SHEET 1 AC3 4 GLU D 30 THR D 31 0 SHEET 2 AC3 4 PHE G 2 LEU G 13 -1 O HIS G 4 N GLU D 30 SHEET 3 AC3 4 VAL G 66 PHE G 77 -1 O TYR G 72 N LEU G 7 SHEET 4 AC3 4 PHE G 44 ILE G 54 -1 N PHE G 44 O PHE G 77 SHEET 1 AC4 2 ARG B 83 TYR B 84 0 SHEET 2 AC4 2 VAL B 132 ILE B 133 -1 O ILE B 133 N ARG B 83 SHEET 1 AC5 3 LYS B 87 LEU B 93 0 SHEET 2 AC5 3 SER B 121 LYS B 130 -1 O THR B 129 N LYS B 87 SHEET 3 AC5 3 THR B 142 PRO B 153 -1 O THR B 147 N VAL B 126 SHEET 1 AC6 2 THR B 97 TRP B 99 0 SHEET 2 AC6 2 PRO B 105 PRO B 107 -1 O SER B 106 N HIS B 98 SHEET 1 AC7 3 PHE B 185 ILE B 187 0 SHEET 2 AC7 3 SER B 190 VAL B 193 -1 O SER B 190 N ILE B 187 SHEET 3 AC7 3 GLN B 468 VAL B 469 -1 O GLN B 468 N VAL B 193 SHEET 1 AC8 4 LYS B 391 ASP B 394 0 SHEET 2 AC8 4 ALA B 196 MET B 200 -1 N GLN B 197 O ASP B 394 SHEET 3 AC8 4 ARG B 484 ASN B 486 1 O ASN B 486 N GLU B 198 SHEET 4 AC8 4 VAL B 523 ASN B 525 -1 O LYS B 524 N LEU B 485 SHEET 1 AC9 5 TYR B 206 ALA B 209 0 SHEET 2 AC9 5 TYR B 215 SER B 223 -1 O GLU B 220 N TYR B 206 SHEET 3 AC9 5 SER B 233 LEU B 240 -1 O ILE B 235 N CYS B 221 SHEET 4 AC9 5 ILE B 256 THR B 259 -1 O VAL B 257 N SER B 238 SHEET 5 AC9 5 VAL B 267 PRO B 268 -1 O VAL B 267 N ALA B 258 SHEET 1 AD1 3 TYR B 531 VAL B 534 0 SHEET 2 AD1 3 ALA B 618 ILE B 627 -1 O CYS B 622 N TYR B 531 SHEET 3 AD1 3 VAL B 662 ASP B 666 -1 O ILE B 665 N ARG B 623 SHEET 1 AD2 4 TYR B 531 VAL B 534 0 SHEET 2 AD2 4 ALA B 618 ILE B 627 -1 O CYS B 622 N TYR B 531 SHEET 3 AD2 4 HIS B 695 CYS B 696 -1 O CYS B 696 N LEU B 626 SHEET 4 AD2 4 LEU B 675 ALA B 676 1 N ALA B 676 O HIS B 695 SHEET 1 AD3 5 GLU B 551 ASN B 552 0 SHEET 2 AD3 5 CYS B 572 HIS B 577 -1 O ILE B 576 N GLU B 551 SHEET 3 AD3 5 THR B 565 VAL B 569 -1 N THR B 565 O HIS B 577 SHEET 4 AD3 5 GLU B 611 TYR B 615 1 O ILE B 612 N PHE B 568 SHEET 5 AD3 5 SER B 602 ASP B 606 -1 N SER B 602 O TYR B 615 SHEET 1 AD4 5 LEU B 747 LEU B 751 0 SHEET 2 AD4 5 SER B 808 GLN B 817 -1 O TYR B 811 N ALA B 748 SHEET 3 AD4 5 LYS B 917 ARG B 927 -1 O SER B 925 N PHE B 810 SHEET 4 AD4 5 GLY B 902 LEU B 911 -1 N ILE B 903 O ARG B 924 SHEET 5 AD4 5 ARG B 859 VAL B 860 -1 N VAL B 860 O GLY B 902 SHEET 1 AD5 7 LEU B 747 LEU B 751 0 SHEET 2 AD5 7 SER B 808 GLN B 817 -1 O TYR B 811 N ALA B 748 SHEET 3 AD5 7 LYS B 917 ARG B 927 -1 O SER B 925 N PHE B 810 SHEET 4 AD5 7 GLY B 902 LEU B 911 -1 N ILE B 903 O ARG B 924 SHEET 5 AD5 7 ILE L 43 LYS L 46 -1 O MET L 44 N VAL B 909 SHEET 6 AD5 7 ILE L 16 CYS L 19 -1 N ILE L 18 O TYR L 45 SHEET 7 AD5 7 GLU L 25 GLU L 27 -1 O ASN L 26 N TYR L 17 SHEET 1 AD6 2 VAL B 759 THR B 760 0 SHEET 2 AD6 2 GLY B 997 ASP B 998 1 O GLY B 997 N THR B 760 SHEET 1 AD7 8 ASN B1025 GLU B1026 0 SHEET 2 AD7 8 ILE B1041 ARG B1050 -1 O ILE B1041 N GLU B1026 SHEET 3 AD7 8 LYS B 934 SER B 937 -1 N ALA B 936 O GLN B1049 SHEET 4 AD7 8 LYS B 942 TYR B 949 -1 O GLY B 943 N PHE B 935 SHEET 5 AD7 8 SER B 793 ASN B 797 1 N VAL B 794 O GLY B 946 SHEET 6 AD7 8 ILE B 965 ILE B 967 -1 O ILE B 966 N ILE B 795 SHEET 7 AD7 8 ILE B 776 ILE B 782 1 N ALA B 781 O ILE B 965 SHEET 8 AD7 8 ILE B1041 ARG B1050 -1 O THR B1046 N SER B 778 SHEET 1 AD8 3 GLU B 827 PHE B 829 0 SHEET 2 AD8 3 LYS B 869 VAL B 871 -1 O THR B 870 N VAL B 828 SHEET 3 AD8 3 ARG B 890 ASP B 891 -1 O ARG B 890 N VAL B 871 SHEET 1 AD9 2 VAL B 865 ILE B 867 0 SHEET 2 AD9 2 THR B 894 PHE B 895 -1 O THR B 894 N ILE B 866 SHEET 1 AE1 2 ILE B1127 ASN B1129 0 SHEET 2 AE1 2 THR B1134 GLU B1136 -1 O THR B1134 N ASN B1129 SHEET 1 AE2 4 THR C 8 LEU C 14 0 SHEET 2 AE2 4 ASN C 18 GLU C 24 -1 O LYS C 20 N GLU C 13 SHEET 3 AE2 4 PHE C 229 SER C 235 -1 O TYR C 231 N PHE C 21 SHEET 4 AE2 4 THR C 179 TYR C 186 -1 N ALA C 180 O GLU C 234 SHEET 1 AE3 5 ILE C 121 SER C 122 0 SHEET 2 AE3 5 VAL C 99 ARG C 106 -1 N THR C 102 O ILE C 121 SHEET 3 AE3 5 GLU C 158 GLY C 168 -1 O ALA C 163 N PHE C 101 SHEET 4 AE3 5 ILE C 44 ASN C 55 -1 N ILE C 44 O GLY C 168 SHEET 5 AE3 5 VAL L 54 PHE L 55 -1 O PHE L 55 N VAL C 50 SHEET 1 AE4 2 ARG C 113 THR C 116 0 SHEET 2 AE4 2 LEU C 149 LEU C 153 -1 O LEU C 153 N ARG C 113 SHEET 1 AE5 5 TYR E 26 LEU E 27 0 SHEET 2 AE5 5 VAL E 60 HIS E 64 -1 O ALA E 63 N LEU E 27 SHEET 3 AE5 5 GLN E 71 PHE E 75 -1 O MET E 72 N VAL E 62 SHEET 4 AE5 5 ARG E 101 VAL E 106 1 O LEU E 103 N PHE E 75 SHEET 5 AE5 5 ILE E 126 LEU E 131 1 O PHE E 130 N ILE E 104 SHEET 1 AE6 2 LYS E 81 VAL E 82 0 SHEET 2 AE6 2 GLY E 109 MET E 110 1 O GLY E 109 N VAL E 82 SHEET 1 AE7 4 GLU E 147 VAL E 150 0 SHEET 2 AE7 4 VAL E 190 SER E 197 -1 O LYS E 192 N VAL E 149 SHEET 3 AE7 4 GLY E 201 GLN E 210 -1 O ARG E 207 N VAL E 191 SHEET 4 AE7 4 ARG E 172 GLN E 174 1 N ILE E 173 O GLN E 210 SHEET 1 AE8 5 MET G 104 PHE G 107 0 SHEET 2 AE8 5 PHE G 98 ILE G 101 -1 N THR G 99 O CYS G 106 SHEET 3 AE8 5 VAL G 84 VAL G 89 -1 N VAL G 88 O GLU G 100 SHEET 4 AE8 5 GLU G 142 ARG G 151 -1 O ILE G 143 N ALA G 87 SHEET 5 AE8 5 PHE G 158 SER G 162 -1 O ILE G 160 N VAL G 148 SHEET 1 AE9 3 TYR I 25 GLU I 28 0 SHEET 2 AE9 3 LEU I 35 ALA I 38 -1 O LEU I 36 N LYS I 27 SHEET 3 AE9 3 GLN I 45 GLU I 47 -1 O GLN I 46 N TYR I 37 SHEET 1 AF1 4 ARG I 80 THR I 81 0 SHEET 2 AF1 4 ALA I 94 GLN I 98 -1 O ALA I 94 N THR I 81 SHEET 3 AF1 4 LEU I 110 CYS I 114 -1 O TYR I 111 N PHE I 97 SHEET 4 AF1 4 ARG I 122 THR I 124 -1 O TRP I 123 N TYR I 112 SHEET 1 AF2 4 ILE K 19 LYS K 23 0 SHEET 2 AF2 4 ALA K 30 ASN K 36 -1 O LEU K 32 N ASN K 22 SHEET 3 AF2 4 LYS K 70 THR K 77 -1 O ILE K 73 N PHE K 33 SHEET 4 AF2 4 VAL K 56 LYS K 62 -1 N LYS K 62 O ILE K 72 SSBOND 1 CYS A 109 CYS A 148 1555 1555 2.04 LINK SG CYS A 71 ZN ZN A2001 1555 1555 2.55 LINK SG CYS A 74 ZN ZN A2001 1555 1555 2.24 LINK SG CYS A 81 ZN ZN A2001 1555 1555 2.23 LINK NE2 HIS A 84 ZN ZN A2001 1555 1555 2.03 LINK SG CYS A 111 ZN ZN A2002 1555 1555 2.29 LINK SG CYS A 154 ZN ZN A2002 1555 1555 2.29 LINK SG CYS A 184 ZN ZN A2002 1555 1555 2.38 LINK OD1 ASP A 495 MG MG A2003 1555 1555 1.84 LINK OD2 ASP A 495 MG MG A2003 1555 1555 2.97 LINK OD1 ASP A 497 MG MG A2003 1555 1555 1.94 LINK OD2 ASP A 497 MG MG A2003 1555 1555 2.98 LINK OD1 ASP A 499 MG MG A2003 1555 1555 2.47 LINK MG MG A2003 O3' U P 145 1555 1555 1.96 LINK SG CYS B1119 ZN ZN B1201 1555 1555 2.35 LINK SG CYS B1122 ZN ZN B1201 1555 1555 2.38 LINK SG CYS B1137 ZN ZN B1201 1555 1555 2.32 LINK SG CYS B1140 ZN ZN B1201 1555 1555 2.37 LINK SG CYS C 88 ZN ZN C 301 1555 1555 2.28 LINK SG CYS C 90 ZN ZN C 301 1555 1555 2.23 LINK SG CYS C 94 ZN ZN C 301 1555 1555 2.33 LINK SG CYS C 97 ZN ZN C 301 1555 1555 2.35 LINK SG CYS I 17 ZN ZN I 201 1555 1555 2.27 LINK SG CYS I 20 ZN ZN I 201 1555 1555 2.35 LINK SG CYS I 39 ZN ZN I 201 1555 1555 2.93 LINK SG CYS I 86 ZN ZN I 202 1555 1555 2.36 LINK SG CYS I 89 ZN ZN I 202 1555 1555 2.33 LINK SG CYS I 114 ZN ZN I 202 1555 1555 2.47 LINK SG CYS I 119 ZN ZN I 202 1555 1555 2.31 LINK SG CYS J 7 ZN ZN J 101 1555 1555 2.34 LINK SG CYS J 10 ZN ZN J 101 1555 1555 2.22 LINK SG CYS J 44 ZN ZN J 101 1555 1555 2.37 LINK SG CYS J 45 ZN ZN J 101 1555 1555 2.52 LINK SG CYS L 19 ZN ZN L 101 1555 1555 2.32 LINK SG CYS L 22 ZN ZN L 101 1555 1555 2.25 LINK SG CYS L 36 ZN ZN L 101 1555 1555 2.21 LINK SG CYS L 39 ZN ZN L 101 1555 1555 2.25 CISPEP 1 GLN A 461 PRO A 462 0 -0.98 CISPEP 2 LYS A 581 PRO A 582 0 -6.39 CISPEP 3 ARG E 52 PRO E 53 0 4.35 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000